gamma-Aminobutyric acid receptors at the ventral surface of the medulla inhibit respiratory motor outflow to the laryngeal musculature.
gamma-Aminobutyric acid receptors at the ventral surface of the medulla inhibit respiratory motor outflow to the laryngeal musculature.
复制标题
髓质腹侧表面的γ-氨基丁酸受体抑制呼吸运动流出到喉部肌肉组织。
DOI：
10.1016/0028-3908(89)90101-9
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发表时间：
1989
影响因子：
4.7
通讯作者：
HoltmanJr,JR
中科院分区：
文献类型：
--
作者：
King,KA;HoltmanJr,JR
激活γ-氨基丁酸（GABA）的作用本实验观察了猫延髓腹侧面GABA受体对喉返神经和膈神经活动的影响，并将GABA对喉返神经和膈神经活动的影响特征与以前已证实的膈神经活动的影响特征进行了比较。髓质应用GABA（0.017-4.05毫克）的中间区域产生了剂量相关的抑制呼吸活动的喉返神经，以及膈神经，最终在呼吸暂停。每根神经的抑制表现为神经活动幅度的降低，呼吸频率无变化。GABA诱导的喉返神经和膈神经活性抑制的起始时间、峰值时间和恢复时间无显著差异。GABA抑制喉返神经和膈神经活动的ED_（50）值及其95%可信区间分别为0.26 mg（0.19-0.36 mg）和0.27 mg（0.20-0.37 mg）。因此，GABA抑制这些神经活性的效力没有显著差异。GABA受体拮抗剂荷包牡丹碱（10 μg）可逆转对喉返神经和膈神经活动的抑制。荷包牡丹碱治疗后各神经恢复时相活动的时间无显著差异。没有显着的变化，无论是喉返神经或膈神经的活动发生后应用GABA的延髓腹侧表面上的吻侧或尾侧区域。这些发现表明，GABA受体，在中间区域上的腹侧表面的髓质，参与调节呼吸运动流出到喉以及隔膜。
The effect of activating γ-aminobutyric acid (GABA) receptors at the ventral surface of the medulla on the activity of the recurrent laryngeal nerve and phrenic nerve was assessed in the cat. Characteristics of the effects of GABA on the activity of the recurrent laryngeal nerve were compared with those on that of the phrenic nerve which has previously been shown to be inhibited by the application of GABA to the ventral surface of the medulla. Application of GABA (0.017–4.05 mg) to the intermediate area produced a dose-related inhibition of respiratory activity in the recurrent laryngeal nerve, as well as the phrenic nerve, that culminated in apnea. The inhibition in each nerve was seen as a decrease in amplitude of nerve activity with no change in respiratory rate. The onset time, peak time and recovery time from GABA-induced inhibition of activity in the recurrent laryngeal and phrenic nerves were not significantly different. The ED50value for GABA and its 95% confidence interval for inhibition of the activities of the recurrent laryngeal and phrenic nerves were 0.26 mg (0.19–0.36 mg) and 0.27 mg (0.20–0.37 mg), respectively. Therefore, the potency of GABA for the inhibition of the activity of these nerves was not significantly different. The GABA receptor antagonist, bicuculline (10 μg), reversed the inhibition of the activities of both the recurrent laryngeal and the phrenic nerves. The time for return of phasic activity in each nerve after bicuculline was not significantly different. No significant changes in the activity of either the recurrent laryngeal or the phrenic nerves occurred following application of GABA to the rostral or caudal areas on the ventral surface of the medulla. These findings indicate that GABA receptors, at the intermediate area on the ventral surface of the medulla, are involved in the regulation of respiratory motor outflow to the larynx as well as to the diaphragm.