A genome screen of families at high risk for Hodgkin lymphoma: evidence for a susceptibility gene on chromosome 4
A genome screen of families at high risk for Hodgkin lymphoma: evidence for a susceptibility gene on chromosome 4
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DOI：
10.1136/jmg.2004.027433
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发表时间：
2005-07-01
影响因子：
4
通讯作者：
Tucker, MA
中科院分区：
文献类型：
--
作者：
Goldin, LR;McMaster, ML;Tucker, MA
自1970年以来，遗传流行病学分支（癌症流行病学和遗传学分部）一直在招募有两个或两个以上HL存活病例的家庭。本研究获得了机构审查委员会的批准，并获得了本报告中所有受试者的知情同意书。在NIH临床中心或实地考察中，我们评估了所有可用的受影响个体和受影响个体的一级亲属，并获得了生物标本。我们还获得了所有HL和NHL病例的原始病理学材料和报告（如可能），并由国家癌症研究所病理学实验室审查。在调查的家庭中，根据受影响和未受影响个体的可用DNA样本数（共254个），44个家庭被判定为可用于连锁研究。这些家庭中有16个已被列入早期的研究连锁和关联的HLA区域。18
METHODS Ascertainment of HL pedigrees The Genetic Epidemiology Branch (Division of Cancer Epidemiology and Genetics) has been recruiting families with two or more living cases of HL since 1970. This study was approved by an institutional review board, and informed consent was obtained on all subjects in this report. At the NIH clinical centre or on field trips, we evaluated all available affected individuals and first degree relatives of those affected, and obtained biospecimens. We also obtained original pathology material and reports for all HL and NHL cases where possible, and these were reviewed by the National Cancer Institute Laboratory of Pathology. Of the families investigated, 44 were judged to be informative for linkage studies, based on the number of available DNA samples (total 254) from affected and unaffected individuals. Sixteen of these families had been included in an earlier study of linkage and association with the HLA region. 18