NUTRITION IMPACT SYMPTOMS: KEY DETERMINANTS OF REDUCED DIETARY INTAKE, WEIGHT LOSS, AND REDUCED FUNCTIONAL CAPACITY OF PATIENTS WITH HEAD AND NECK CANCER BEFORE TREATMENT
NUTRITION IMPACT SYMPTOMS: KEY DETERMINANTS OF REDUCED DIETARY INTAKE, WEIGHT LOSS, AND REDUCED FUNCTIONAL CAPACITY OF PATIENTS WITH HEAD AND NECK CANCER BEFORE TREATMENT
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DOI：
10.1002/hed.21174
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发表时间：
2010-03-01
影响因子：
2.9
通讯作者：
Baracos, Vickie E.
中科院分区：
文献类型：
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作者：
Kubrak, Catherine;Olson, Kaerin;Baracos, Vickie E.
背景我们的目的是评估头颈癌患者的患病率以及症状与饮食摄入量减少、体重和功能能力的关系。在治疗前，采用患者基因评定的主观总体评估对341例患者进行了前瞻性筛选。Logistic分析用于将症状与饮食摄入量减少、体重和功能能力相关。进行累积风险分析，以确定每种症状的体重减轻时间和风险。生存分析采用考克斯比例风险模型。厌食症、吞咽困难、口腔溃疡等是饮食摄入量和体重减少的重要预测因素。症状的存在加速了体重减轻的时间和可能性。体重指数
Background. Our aim was to evaluate the prevalence and relationship of symptoms with reduced dietary intake, weight, and functional capacity in patients with head and neck cancer.Methods. Three hundred forty-one patients were prospectively screened with the patient-gene rated subjective global assessment before treatment. Logistic analysis was used to relate symptoms to reduced dietary intake, weight, and functional capacity. Cumulative hazard analysis was performed to determine the time and risk of weight loss of each symptom. Survival analysis was performed with Cox proportional hazards model.Results. Anorexia, dysphagia, mouth sores, and others were significant predictors of reduced dietary intake and weight. Symptom presence accelerated the time and probability of weight loss. Body mass index