Punica granatum (pomegranate) peel extract exerts potent antitumor and anti-metastasis activity in thyroid cancer (vol 6, pg 84523, 2016)
Punica granatum (pomegranate) peel extract exerts potent antitumor and anti-metastasis activity in thyroid cancer (vol 6, pg 84523, 2016)
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Punica granatum（石榴）皮提取物对甲状腺癌具有有效的抗肿瘤和抗转移活性
DOI：
10.1039/c7ra90068f
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发表时间：
2017
期刊：
影响因子：
3.9
通讯作者：
Li Shuangqing
中科院分区：
文献类型：
--
作者：
Li Yujue;Ye Tinghong;Yang Fangfang;Hu Mingxing;Liang Libo;He He;Li Zhipeng;Zeng Anqi;Li Yali;Yao Yuqin;Xie Yongmei;An Zhenmei;Li Shuangqing
近十年来，甲状腺癌的发病率在世界范围内呈明显上升趋势。然而，过度治疗往往发生在甲状腺癌没有新的和有效的方法正在探索。本研究评价了一种草药石榴皮提取物（PoPx）在体外和体内对甲状腺癌的抗癌活性。PoPx能有效抑制两种甲状腺癌细胞系的增殖，并诱导癌细胞凋亡。PoPx还可降低线粒体膜电位（Δ Pm），提示PoPx可能通过介导的凋亡途径诱导细胞凋亡。此外，PoPx通过下调基质金属蛋白酶-9（MMP-9）的表达，显著损害甲状腺癌细胞的迁移和侵袭。更重要的是，PoPx通过减少细胞增殖和诱导细胞凋亡显著抑制BCPAP荷瘤小鼠模型中的肿瘤生长。这些发现表明PoPx可能是一种有效的植物化学制剂。
The incidence of thyroid carcinoma has obviously been rising throughout the world during the past ten years. However, over-treatment has usually occurred in thyroid carcinoma without new and effective approaches being explored. In this study, Punica granatum (pomegranate) peel extract (PoPx), a kind of herb, was evaluated for its anticancer activity to thyroid carcinoma in vitro and in vivo. PoPx potently suppressed proliferation in two kinds of thyroid cancer cell lines, and induced cancer cell apoptosis. PoPx could also decrease the mitochondrial membrane potential (ΔΨm), indicating that PoPx may induce apoptosis via a mitochondria-mediated apoptotic pathway. In addition, PoPx markedly impaired thyroid cancer cell migration and invasion by down-regulating the expression of matrix metalloproteinase-9 (MMP-9). More importantly, PoPx significantly inhibited tumor growth in the BCPAP-bearing mice model by reducing cell proliferation and inducing apoptosis. These findings suggest that PoPx could be an effective phytochemical agent.