Model storage, exchange and integration.
Model storage, exchange and integration.
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DOI：
10.1186/1471-2202-7-s1-s11
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发表时间：
2006-10-30
期刊：
影响因子：
2.4
通讯作者：
Le Novère N
中科院分区：
文献类型：
--
作者：
Le Novère N
计算系统神经生物学领域正在迅速成熟。如果人们希望它在新的综合神经生物学中发挥其核心作用，就需要促进量化模型的重复使用。社区必须制定标准和指导方针，以便最大限度地传播其科学成果，同时也使其更值得信赖。近年来，各种研究项目都致力于解决定量模型的句法和语义问题。最近，国际倡议BioModels.net启动了三个项目：(1)Miriam是一个标准，用于管理和注释模型，以促进它们的重复使用。(2)系统生物学本体论是一组受控词汇表，旨在与模型结合使用，以表征其组件。(3)Biomodels数据库是一个允许生物学家存储、搜索和检索已发表的生物学兴趣数学模型的资源。我们期望这些资源，再加上SBML等形式语言的使用，将支持对量化模型进行卓有成效的交流和再利用。
The field of Computational Systems Neurobiology is maturing quickly. If one wants it to fulfil its central role in the new Integrative Neurobiology, the reuse of quantitative models needs to be facilitated. The community has to develop standards and guidelines in order to maximise the diffusion of its scientific production, but also to render it more trustworthy. In the recent years, various projects tackled the problems of the syntax and semantics of quantitative models. More recently the international initiative BioModels.net launched three projects: (1) MIRIAM is a standard to curate and annotate models, in order to facilitate their reuse. (2) The Systems Biology Ontology is a set of controlled vocabularies aimed to be used in conjunction with models, in order to characterise their components. (3) BioModels Database is a resource that allows biologists to store, search and retrieve published mathematical models of biological interests. We expect that those resources, together with the use of formal languages such as SBML, will support the fruitful exchange and reuse of quantitative models.