OCTA vessel density changes in the macular zone in glaucomatous eyes
OCTA vessel density changes in the macular zone in glaucomatous eyes
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DOI：
10.1007/s00417-018-3965-1
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发表时间：
2018-08-01
影响因子：
2.7
通讯作者：
Grisanti, S.
中科院分区：
文献类型：
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作者：
Lommatzsch, C.;Rothaus, K.;Grisanti, S.
为了评价黄斑光学相干断层扫描血管造影术（OCTA）是否能检测青光眼眼浅表和深部血管丛中血管密度（VD）的改变，并比较单个VD参数的诊断效用，使用两种OCTA设备（AngioPlex-Zeiss Meditec，Inc.，美国加利福尼亚州都柏林和AngioVue-OptoVue，Inc.，Fremont，CA，USA）。所有研究参与者既没有血管病变，糖尿病，也没有血管活性药物。在两个不同的分割水平（浅[SL]和深[DL]视网膜血管丛）用6 x 6 mm黄斑扫描测量黄斑VD，VD与各种结构和功能测量相关。为了检验区分有无青光眼的准确性，我们计算了受试者工作特征（ROC）曲线和曲线下面积（AUC）。青光眼眼SL和DL的黄斑VD均显著低于健康眼（p = SL < 0.0001; DL = 0.009）。SL和DL之间的VD无显著差异（p = 6.60，中心点10（-18））。青光眼患者的VD下降最多的是黄斑下区。VD与年龄和屈光不正无相关性，但与眼压、初诊时间、平均偏差、神经节细胞复合体、视乳头周围视网膜神经纤维层厚度、杯盘比和边缘面积中度至高度相关。在14个黄斑部VD的个体特征中，SL中的整个VD具有最好的诊断准确性（77.6%），以ROC下的面积测量。它可以作为独立于视神经检测青光眼的额外诊断工具。
To evaluate whether macular optical coherence tomography angiography (OCTA) can detect altered vessel density (VD) in the superficial and deep vascular plexus in glaucomatous eyes and to compare the diagnostic utility of the individual VD parameters.The macular VD of 135 eyes, comprising 85 eyes diagnosed with glaucoma and 50 healthy control eyes, was examined using two OCTA devices (AngioPlex-Zeiss Meditec, Inc., Dublin, CA, USA, and AngioVue-OptoVue, Inc., Fremont, CA, USA). All study participants had neither vascular pathology, diabetes, nor vasoactive medication. The macular VD was measured at two different levels of segmentation (superficial [SL] and deep [DL] retinal vascular plexus) with a 6 x 6-mm macula scan, and VD was correlated with various structural and functional measurements. In order to test the accuracy of differentiation between eyes with and without glaucoma, we calculated the receiver operating characteristic (ROC) curve and the area under the curve (AUC).Macular VD was significantly lower in both SL and DL in glaucomatous eyes than in healthy eyes (p = SL < 0.0001; DL = 0.009). There was no significant difference in VD between the SL and the DL (p = 6.60 center dot 10(-18)). The greatest reduction of VD in glaucomatous eyes was found in the inferior macular sector. There was no correlation of VD with age or refractive error but moderate to high correlation with intraocular pressure, time of initial diagnosis, mean deviation, ganglion cell complex, peripapillary retinal nerve fiber layer thickness, cup to disc ratio, and rim area. Among the 14 individual features of macular VD, whole VD in the SL had the best diagnostic accuracy (77.6%) as measured by the area under the ROC.OCTA detects glaucomatous damage by measuring the macular vessel density in the superficial and deep retinal vascular plexus. It can be an additional diagnostic tool to detect glaucoma independently of the optic nerve.