Pulmonary artery structural changes in two colonies of rats with different sensitivity to chronic hypoxia.
Pulmonary artery structural changes in two colonies of rats with different sensitivity to chronic hypoxia.
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发表时间：
1987-07
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通讯作者：
D. Langleben;Rosemary C. Jones;M. Aronovitz;N. Hill;OU LO-CHANG;Lynne M. Reid
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作者：
D. Langleben;Rosemary C. Jones;M. Aronovitz;N. Hill;OU LO-CHANG;Lynne M. Reid
慢性缺氧会导致斯普拉格-道利大鼠的山顶群体比麦迪逊群体更严重的肺动脉高压，并且还会导致更大的红细胞增多症和血管收缩。这项研究检查了肺动脉床的结构特征，这是缺氧性高血压的另一个影响因素。低压缺氧14天后，Hilltop大鼠的腺泡内动脉变得肌肉化，腺泡内和腺泡前动脉的内侧厚度更大。在 Hilltop 对照大鼠中，在更多的腺泡内动脉中发现了肌肉，但矛盾的是，急性缺氧血管收缩较少。因此，虽然在慢性缺氧中，肌肉增加与肺动脉高压相关，但在对照大鼠中，这种储备似乎是正确的。然而，对照山顶大鼠的肌肉增加可能导致慢性缺氧后出现更大的肌肉化。
Chronic hypoxia causes more severe pulmonary hypertension in the Hilltop colony of Sprague-Dawley rats than in the Madison colony and also greater polycythemia and vasoconstriction. This study examines the structural features of the pulmonary artery bed, another contributing factor to hypoxic hypertension. After 14 days of hypobaric hypoxia, in Hilltop rats, more of the intraacinar arteries became muscular, and the medial thickness of intraacinar and preacinar arteries was greater. In Hilltop control rats, muscle was found in more intraacinar arteries, but, paradoxically, acute hypoxic vasoconstriction was less. Thus, while in chronic hypoxia increased muscle correlates with pulmonary hypertension, in control rats the reserve seems to be true. The increased muscle in control Hilltop rats could, however, predispose to the greater muscularization seen after chronic hypoxia.