The factor structure of autistic traits
The factor structure of autistic traits
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DOI：
10.1111/j.1469-7610.2004.00266.x
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发表时间：
2004-05-01
影响因子：
7.6
通讯作者：
Przybeck, T
中科院分区：
文献类型：
--
作者：
Constantino, JN;Gruber, CP;Przybeck, T
背景：尽管《精神疾病诊断与统计手册》第四版（DSM - IV）要求在三个标准领域存在症状才能诊断自闭症，但这些领域在表型上的独立程度是一个未解决的重要问题。自闭症综合征内表型的确定对于自闭症的遗传学和神经生物学研究可能非常有用，但前提是它们代表该疾病真正独立的子领域。
方法：在本研究中，我们使用来自226名患有和未患有广泛性发育障碍的儿童精神病患者的数据，通过对《自闭症诊断访谈修订版》（ADI - r）的数据进行聚类分析以及对《社会反应量表》（SRS，一种自闭症特征的定量遗传学测量方法，以前称为《社会互惠量表》）的数据进行主成分因子分析，来检验自闭症特征的因子结构。
结果：结果与存在一个单一的、连续分布的潜在因子相符，这导致自闭症在三个标准领域（社交缺陷、语言缺陷以及重复/刻板行为）出现不同的表型表现。
结论：这些分析总体上未能支持自闭症谱系障碍中存在独立的功能障碍子领域。通过将自闭症症状视为数量性状，并参考正在进行的关于互惠社会行为核心缺陷的发展和现象学研究，未来关于遗传/神经生物学标记与自闭症症状学之间关联的研究可能会得到加强。
Background: Although DSM-IV requires symptoms in three criterion domains for a diagnosis of autistic disorder, the extent to which those domains are phenotypically independent is an unanswered and important question. The identification of endophenotypes'of the autistic syndrome may be very useful for genetic and neurobiologic studies of autism, but only if they represent truly independent sub domains of the disorder. Methods: In this study we examined the factor structure of autistic traits using data from 226 child psychiatric patients with and without pervasive developmental disorders, employing cluster analysis of data from the Autism Diagnostic Interview-Revised (ADI-r) and principal components factor analysis of data from the Social Responsiveness Scale (SRS, a quantitative genetic measure of autistic traits formerly known as the Social Reciprocity Scale). Results: The results were consistent with the existence of a singular, continuously distributed underlying factor, resulting in disparate phenotypic manifestations across the three criterion domains for autistic disorder (social deficits, language deficits, and repetitive/ stereotypic behaviors). Conclusion: The analyses generally failed to support the existence of independent sub domains of dysfunction in autism spectrum conditions. Future studies of the association between genetic/ neurobiologic markers and autistic symptomatology may be enhanced by approaches which consider autistic symptoms as quantitative traits, and which are informed by ongoing research on the development and phenomenology of core deficiencies in reciprocal social behavior.