Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease
Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease
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DOI：
10.1093/intimm/dxg007
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发表时间：
2003-01-01
影响因子：
4.4
通讯作者：
Yeung, RSM
中科院分区：
文献类型：
--
作者：
Duong, TT;Silverman, ED;Yeung, RSM
川崎病（KD）是一种多系统血管炎，是发达国家儿童获得性心脏病的主要原因。干酪乳杆菌细胞壁提取物引起的小鼠冠状动脉炎与儿童KD相似。在这里，我们报告了对酪蛋白乳酸菌细胞壁提取物的反应具有超抗原介导反应的所有特征：初始T细胞的显著增殖，非经典的主要组织相容性限制，不同类别11分子呈递超抗原的效率等级，抗原呈递的要求，但不加工，以非克隆，TCR v - β链依赖的方式刺激T细胞。这种超抗原活性与诱导小鼠冠状动脉炎的能力直接相关。综上所述，我们的研究结果表明，干酪乳杆菌细胞壁提取物的超抗原活性是诱导冠状动脉疾病的原因。
Kawasaki disease (KD) is a multisystem vasculitis and the leading cause of acquired heart disease in children of the developed world. Lactobacillus casei cell wall extract-induced coronary arteritis in mice mirrors KD in children. Here, we report that responses to L. casei cell wall extract possess all the hallmarks of a superantigen-mediated response: marked proliferation of naive T cells, non-classical major histocompatibility restriction with a hierarchy in the efficiency of different class 11 molecules to present this superantigen, a requirement for antigen presentation, but not processing, and stimulation of T cells in a non-clonal, TCR V-beta chain-dependent fashion. This superantigenic activity directly correlates with the ability to induce coronary arteritis in mice. Taken together, our findings demonstrate that superantigenic activity in L. casei cell wall extract is responsible for induction of coronary artery disease.