MicroRNA-21 as therapeutic target in cancer and cardiovascular disease.
MicroRNA-21 as therapeutic target in cancer and cardiovascular disease.
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DOI：
10.2174/157489010793351962
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发表时间：
2010-11-01
期刊：
影响因子：
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通讯作者：
Bonci, Desiree
中科院分区：
文献类型：
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作者：
Bonci, Desiree
MicroRNAs （miRNAs）是一类控制互补靶信使rna表达的小非编码rna。在包括癌症和心脏病在内的各种疾病状态中已经描述了mirna的失调。在癌症和各种形式的心血管疾病中，有一种特定的miRNA一直被报道上调，这就是miR-21。MiR-21具有致癌活性，因此被认为是一种肿瘤因子。在心血管系统中，miR-21在成纤维细胞中富集，有助于纤维化和心力衰竭的发展。因此，MiR-21成为开发针对多种癌症和心脏病的治疗策略的有趣候选者。事实上，用抗mir -21寡核苷酸治疗可以降低乳腺癌的生长。在心脏病模型中，合成miRNA拮抗剂（antagomirs）抑制miR-21可改善心功能。在左心室压力过载的miR-21敲除小鼠中观察到同样的有益效果，强调了miR-21作为治疗靶点的关键作用。我们在这里概述了miR-21调节在癌症和心血管疾病治疗中的应用的专利现状。
MicroRNAs (miRNAs) are a broad class of small non-coding RNAs that control expression of complementary target messenger RNAs. Dysregulation of miRNAs has been described in various disease states including cancer and cardiac disease. A particular miRNA that was consistently reported to be upregulated in both cancer and various forms of cardiovascular diseases is miR-21. MiR-21 exerts oncogenic activity and therefore is considered as an oncomir. In the cardiovascular system miR-21 is enriched in fibroblasts and contributes to the development of fibrosis and heart failure. MiR-21 therefore emerges as an interesting candidate for the development of therapeutic strategies against many forms of cancer as well as heart diseases. Indeed, treatment with anti-miR-21 oligonucleotides reduced breast cancer growth. Inhibition of miR-21 by synthetic miRNA antagonists (antagomirs) improved heart function in a cardiac disease model. The same beneficial effects were observed in miR-21 knockout mice subjected to pressure-overload of the left ventricle underlining the key role of miR-21 as a therapeutic target. We here overview the current patent situation about the therapeutic use of miR-21 modulation in cancer and cardiovascular disease.