Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma
Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma
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DOI：
10.1007/s10552-007-9082-9
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发表时间：
2008-03-01
影响因子：
2.3
通讯作者：
Nieters, Alexandra
中科院分区：
文献类型：
--
作者：
Hoeft, Birgit;Becker, Nikolaus;Nieters, Alexandra
目的有限的证据表明炎症过程在淋巴瘤病因学中的重要性。为了进一步研究在这方面，我们调查了遗传变异的作用，在关键的炎症因子，非甾体抗炎药[NSAID]的使用，和他们的联合作用在lymphomagenesis.Methods该研究包括710例对照对，匹配的性别，年龄和研究区域。我们检查了常规NSAID使用与以下基因多态性的关联：前列腺素-内过氧化物合酶-2（COX 2）、前列腺素E合酶（PTGES）、白细胞介素-1 α（伊利亚）、白细胞介素-1 β（ILIB）和白细胞介素-1受体拮抗剂（ILIRA），应用逻辑回归计算比值比（OR）和95%置信区间（95%CI）结果定期使用NSAID可轻微降低B-NHL的发病风险（OR = 0. 8，95% CI = 0. 61）。1）。对于T-NHL，COX 2 rs 2745557 A等位基因赋予2.2倍（95%CI = 1.1-4.5），ILIRN rs 454078 T等位基因的纯合性与4.5倍（95%CI = 1.4-13.9）的风险升高相关，然而，基于稀疏数据。ILI单倍型5与非NSAID常规使用者B-NHL风险增加43%相关，但与常规使用者B-NHL风险降低70%相关（交互作用p值< 0.001）。结论这些结果表明NSAID使用和ILI单倍型对B-NHL风险的联合作用相关。
Objective Limited evidence suggests the importance of inflammatory processes for the etiology of lymphomas. To further research in this area, we investigated the role of genetic variants in key inflammatory factors, non-steroidal anti-inflammatory drug [NSAID] use, and their joint effect in lymphomagenesis.Methods The study comprised 710 case-control pairs, matched for gender, age, and study region. We examined the association of regular NSAID use and polymorphisms in prostaglandin-endoperoxide synthase-2 (COX2), prostaglandin E synthase (PTGES), interleukin-1 alpha (ILIA), IL-1 beta (ILIB), and IL-1 receptor antagonist (ILIRA), and lymphoma risk by applying logistic regression to calculate odds ratios (OR) and 95% confidence intervals (95% CI).Results Regular NSAID use was associated with a slightly reduced risk of B-NHL (OR = 0.8, 95% Cl = 0.61. 1). For T-NHL, the COX2 rs2745557 A-allele conferred a 2.2-fold (95% Cl = 1.1-4.5) and homozygosis for the ILIRN rs454078 T-allele was associated with a 4.5-fold (95% Cl = 1.4-13.9) elevated risk, however, based on sparse data. ILI haplotype 5 was associated with a statistically significant 43% increased risk for B-NHL among non-regular users of NSAIDs, but a 70% decreased risk for regular users (p-value for interaction < 0.001).Conclusions These results suggest the relevance of joint effects between NSAID use and ILI haplotypes on the risk of B-NHL.