Mediterranean diet reduces thromboxane A2 production in atrial fibrillation patients
Mediterranean diet reduces thromboxane A2 production in atrial fibrillation patients
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DOI：
10.1016/j.clnu.2014.09.011
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发表时间：
2015-10-01
影响因子：
6.3
通讯作者：
Violi, Francesco
中科院分区：
文献类型：
--
作者：
Pignatelli, Pasquale;Pastori, Daniele;Violi, Francesco
Background & aims: Platelet activation plays a major role in cardiovascular events (CVEs). Mediterranean diet (Med-Diet) reduces the incidence of stroke and myocardial infarction but it is still unclear if it affects platelet activation. Aim of the study was to evaluate the effect of Med-Diet on the Urinary excretion of 11-dehydro-thromboxane (Tx) B2, a marker of in vivo platelet activation, in patients with atrial fibrillation (AF).Methods: Prospective observational cohort study including 801 non-valvular AF patients on chronic treatment with warfarin/acenocumarol referring to I Medical Clinic - Atherothrombosis Center of Sapienza University of Rome, Italy, from February 2008 to December 2013. Adherence to Med-Diet was evaluated by a short nine-items dietary questionnaire. Urinary excretion of 11-dehydro-TxB2 was measured in all patients.Results: Mean follow-up was 33.9 (+/- 19.8) months, yielding 2223 patient/year of observation. Mean age of patients was 73.3 (+/- 8.9) years, 43.7% were female. Median value of urinary TxB2 was 105.5 [60.0 -190.0] ng/mg creatinine. We found a significant inverse correlation between total Med-Diet score and 11-dehydro-TxB2 values (Rs: -0356, p < 0.001). In a multivariable stepwise linear regression analysis, history of stroke/TIA (beta = 0.146, p = 0.003), olive oil (beta = -0.130, p = 0.007), wine (beta = -0.102, p = 0.036) and antiplatelet drugs (beta = -0.098, p = 0.045) were independently associated to 11-dehydro-TxB2. We found no differences in the rate of ischemic or bleeding events across tertiles of Med-Diet score during follow-up.Conclusions: Med-Diet adherence is inversely associated to urinary excretion of 11-dehydro-TxB2, suggesting that Med-Diet may favorably affect platelet function in AF patients. Clinical Trial RegistrationClinicalTrials.gov NCT01882114. (C) 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
