Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice.
Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice.
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DOI：
10.1038/srep46247
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发表时间：
2017-04-12
影响因子：
4.6
通讯作者：
Sakaguchi M
中科院分区：
文献类型：
--
作者：
Purple RJ;Sakurai T;Sakaguchi M
在睡眠过程中通过条件刺激对记忆进行外部操纵是研究睡眠过程中记忆加工的一种新方法。然而，在快速眼动或非快速眼动睡眠期间出现CS是否会增强或消除恐惧记忆还没有明确的描述。在这项研究中，小鼠接受了由听觉CS与足部电击组成的痕量恐惧条件反射，听觉CS在随后的快速眼动或非快速眼动睡眠中重现。在非快速眼动（NREM）而非快速眼动（REM）睡眠期间接受听觉提示的小鼠在随后的听觉CS呈现时表现出恐惧记忆受损。这些发现对睡眠中线索的使用具有启示意义，并促进了我们对快速眼动和非快速眼动睡眠在记忆巩固中的作用的理解。
Externally manipulating memories by presenting conditioned stimuli (CS) during sleep is a new approach to investigating memory processing during sleep. However, whether presenting a CS during REM or NREM sleep enhances or extinguishes fear memory has not been clearly delineated. In this study, mice underwent trace fear conditioning consisting of an auditory CS paired with a foot shock, and the auditory CS was re-presented during subsequent REM or NREM sleep. Mice that received auditory cueing during NREM but not REM sleep showed impaired fear memory upon later presentation of the auditory CS. These findings have implications for the use of cueing during sleep and advance our understanding of the role of REM and NREM sleep in memory consolidation.