Mitotic and nonmitotic hair cell regeneration in the bullfrog vestibular otolith organs
Mitotic and nonmitotic hair cell regeneration in the bullfrog vestibular otolith organs
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DOI：
10.1111/j.1749-6632.1996.tb15693.x
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Schuff, NR
中科院分区：
文献类型：
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作者：
Baird, RA;Steyger, PS;Schuff, NR
毛细胞是听觉和前庭器官的主要受体，是一种神经上皮细胞，其特征是顶端毛束由单个真纤毛（动纤毛）和大量充满肌动蛋白的静纤毛组成。这些特殊的细胞非常容易受到噪音、感染和耳毒性药物的损害。~~直到最近，人们普遍认为哺乳动物的毛细胞只能 在胚胎发育过程中产生，一旦在成熟动物中丢失，就会永远消失（但请参见参考文献6-8）。然而，许多研究表明，两栖动物、鱼类和鸟类的前庭器官在整个成年过程中继续以低水平产生新的毛细胞。此外，两栖动物的前庭器官，如鸟类13-17和鱼类的前庭器官，在庆大霉素耳致性消除现有毛细胞后，仍保留快速再生新毛细胞的能力。
Hair cells, the primary receptors of the auditory and vestibular organs, are neuroepithelial cells characterized by apical hair bundles composed of a single true cilium-the kinocilium-and a large number of actin-filled stereocilia.’J These specialized cells are highly susceptible to damage by noise, infections, and ototoxic dr~ gs.~-~ Until recently, it was generally accepted that hair cells in mammals could only be produced during embryonic development and that, once lost in mature animals, were gone forever (but see refs. 6-8). Many studies have shown, however, that the vestibular organs of amphibians, fish, and birds continue to produce new hair cells at a low level throughout adult Moreover, the amphibian vestibular organs, like those in birdsl3-l7 and fish, ls retain the capacity to rapidly regenerate new hair cells following the elimination of existing hair cells by gentamicin ototo~ icity.’~