A single exercise bout and locomotor learning after stroke: physiological, behavioural, and computational outcomes
A single exercise bout and locomotor learning after stroke: physiological, behavioural, and computational outcomes
复制标题
DOI：
10.1113/jp275881
复制
发表时间：
2018-05-15
影响因子：
5.5
通讯作者：
Reisman, Darcy S.
中科院分区：
文献类型：
--
作者：
Charalambous, Charalambos C.;Alcantara, Carolina C.;Reisman, Darcy S.
急性高强度运动与运动练习相结合，可以改善神经功能完好的成年人的运动学习能力。然而，运动是否能提高脑卒中后运动学习的保留能力尚不清楚。在这里，我们研究了运动强度和时间对中风后新运动学习任务（即分离式带跑步机行走）保留的影响。37名中风后患者参加了两个疗程，间隔24小时，并被分配到主动控制（CON），跑步机步行（TMW）或在循环计力器（TBE）上进行全身锻炼。在第1阶段，所有组在运动学习任务之前（CON和TMW）或之后（TBE）进行低（CON）或高（TMW和TBE）强度的短时间运动（约5min）。在两组实验中，运动学习任务是在分离式带跑步机上以2:1的速度比（100%和50%的快速舒适步行速度）步行15分钟。为了测试运动对24小时记忆的影响，我们应用了行为和计算分析。行为学数据显示，与对照组相比，高强度组的24小时记忆保留率都不高，计算数据显示，24小时记忆保留率是由于感觉运动适应的学习过程较慢。我们的研究结果表明，急性运动与运动适应任务相结合，无论其强度和时间如何，都不能改善中风后新运动任务的保留。我们假设运动对运动学习的影响可能是特定环境的（例如运动学习和/或任务类型），并与遗传变异的存在相互作用（BDNF Val66Met）。
Acute high-intensity exercise coupled with motor practice improves the retention of motor learning in neurologically intact adults. However, whether exercise could improve the retention of locomotor learning after stroke is still unknown. Here, we investigated the effect of exercise intensity and timing on the retention of a novel locomotor learning task (i.e. split-belt treadmill walking) after stroke. Thirty-seven people post stroke participated in two sessions, 24h apart, and were allocated to active control (CON), treadmill walking (TMW), or total body exercise on a cycle ergometer (TBE). In session 1, all groups exercised for a short bout (approximate to 5min) at low (CON) or high (TMW and TBE) intensity and before (CON and TMW) or after (TBE) the locomotor learning task. In both sessions, the locomotor learning task was to walk on a split-belt treadmill in a 2:1 speed ratio (100% and 50% fast-comfortable walking speed) for 15min. To test the effect of exercise on 24h retention, we applied behavioural and computational analyses. Behavioural data showed that neither high-intensity group showed greater 24h retention compared to CON, and computational data showed that 24h retention was attributable to a slow learning process for sensorimotor adaptation. Our findings demonstrated that acute exercise coupled with a locomotor adaptation task, regardless of its intensity and timing, does not improve retention of the novel locomotor task after stroke. We postulate that exercise effects on motor learning may be context specific (e.g. type of motor learning and/or task) and interact with the presence of genetic variant (BDNF Val66Met).