TRENDS IN RIGHT AND LEFT-SIDED COLON CANCER
TRENDS IN RIGHT AND LEFT-SIDED COLON CANCER
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DOI：
10.1007/bf02553382
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发表时间：
1983-01-01
影响因子：
3.9
通讯作者：
OFALLON, WM
中科院分区：
文献类型：
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作者：
BEART, RW;MELTON, LJ;OFALLON, WM
这项基于人群的研究对1940年至1979年间明尼苏达州罗切斯特居民中诊断出的668例新病例进行了研究，证实了近端与远端结直肠癌的比例不断增加。这一变化是由于近端病变的发生率上升（从1940-59年的15.1/100，000人-年上升到1960-79年的17.3/100，000人-年），同时远端病变的发生率下降（从35.5/100，000人-年下降到28.2/100，000人-年）。定义或转诊模式的变化在这些观察中没有作用，尽管诊断能力的提高可能对近端病变的发生率有影响。这些不一致的变化，发病率强烈表明，近端和远端结肠癌是不同的疾病或有不同的发病机制。发病率的变化与初次诊断时临床特征的一致性差异无关。
The increasing ratio of proximal to distal colorectal carcinomas was confirmed in this population-based study of 668 new cases diagnosed among Rochester, Minnesota residents between 1940 and 1979. The change was due to a rise in the incidence of proximal lesions (from 15.1 per 100,000 person-years in 1940–59 to 17.3 per 100,000 in 1960–79) and a simultaneous fall in the incidence of distal lesions (from 35.5 to 28.2 per 100,000 person-years). Changes in definitions or referral patterns played no role in these observations, although improved diagnostic capabilities may have had an impact on the incidence of proximal lesions. These discrepant changes in incidence strongly suggest that proximal and distal colonic cancers are different diseases or have a different pathogenesis. The changing incidence rates were not associated with consistent differences in clinical characteristics at the time of initial diagnosis.