The correlation between asthma control and health status: the GOAL study
The correlation between asthma control and health status: the GOAL study
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DOI：
10.1183/09031936.00128505
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发表时间：
2007-01-01
影响因子：
24.3
通讯作者：
Pedersen, S. E.
中科院分区：
文献类型：
--
作者：
Bateman, E. D.;Bousquet, J.;Pedersen, S. E.
本研究在未控制的哮喘患者中，使用哮喘生活质量问卷（AQLQ）评估了指南衍生的哮喘控制与健康相关生活质量之间的关系，这些患者的治疗旨在达到尽可能高的控制水平。一项平行组研究比较了丙酸氟替卡松（FP）和沙美特罗/丙酸氟替卡松复方制剂（SFC）在实现两项指南衍生的复合控制指标方面的疗效：完全控制（TC）和良好控制（WC）哮喘。未达到这些水平被归类为控制不佳（NWC）。增加剂量，直至患者达到TC或达到最大剂量。在研究的剩余时间内维持该剂量。在基线和每次门诊访视时评估AQLQ。AQLQ评分在整个研究期间均有所改善，在达到TC和WC的患者中达到接近最高水平，并且三个对照组的52周平均评分在统计学上有显著差异。有临床意义的改善（较基线的平均变化）为：TC组（SFC 1.9，FP 1.8），WC组（SFC 1.5，FP 1.5）和NWC组（SFC 1.0，FP 0.9）。总之，旨在控制哮喘的治疗将健康相关的生活质量提高到接近正常的水平。完全控制和良好控制之间哮喘生活质量问卷评分的差异证实，患者甚至可以区分这些高水平的控制。
The present study examined the association between guideline-derived asthma control and health-related quality of life, assessed using the Asthma Quality of Life Questionnaire (AQLQ), in patients with uncontrolled asthma whose treatment was directed towards achieving the highest possible level of control.The present randomised, double-blind, parallel-group study compared the efficacy of fluticasone propionate (FP) and salmeterol/fluticasone propionate combination (SFC) in achieving two composite, guideline-derived measures of control: total control (TC) and well-controlled (WC) asthma. Not achieving these levels was classed as not well-controlled (NWC). Doses were augmented until patients achieved TC or reached the maximum dose. This dose was maintained for the remainder of the study. AQLQ was assessed at baseline and at each clinic visit.AQLQ scores improved throughout the study, reaching near-maximal levels in patients achieving TC and WC, and 52-week mean scores in the three control groups were statistically significantly different. Clinically meaningful improvements (mean change from baseline) were: TC group (SFC 1.9, FP 1.8), WC (SFC 1.5, FP 1.5) and NWC (SFC 1.0, FP 0.9).In conclusion, the treatment aimed at controlling asthma improves the health-related quality of life to levels approaching normal. The difference in Asthma Quality of Life Questionnaire scores between total control and well-controlled confirms that patients distinguish even between these high levels of control.