LPS induces migration of bone marrow cells in LPS-nonresponsive C3H/HeJ mice.
LPS induces migration of bone marrow cells in LPS-nonresponsive C3H/HeJ mice.
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LPS 诱导 LPS 无反应的 C3H/HeJ 小鼠骨髓细胞迁移。
DOI：
10.1269/jrr.25.91
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发表时间：
1984
影响因子：
2
通讯作者：
K. Mori
中科院分区：
文献类型：
--
作者：
S. Aizawa;I. Amaki;J. Fujita;M. Tsurusawa;K. Mori
为了确定LPS无应答（C3H/HeJ）小鼠造血干细胞（cfu）对LPS可能的迁移反应，在脾切除的C3H/HeJ小鼠中研究了LPS治疗后cfu和粒细胞-巨噬细胞祖细胞（CFUc）数量的变化。脾切除术消除了LPS诱导的骨髓干细胞（cfu和CFUc）在LPS应答和非应答小鼠中的减少。脾切除术能显著促进C3H/slc小鼠辐照后骨髓干细胞的恢复，但在C3H/HeJ小鼠中未观察到这种增强。这些数据表明，C3H/HeJ小鼠脾脏中造血干细胞数量的增加取决于造血干细胞从骨髓向脾脏的迁移。因此，cfu的扩大与全身造血干细胞数量的增加无关。LPS的迁移诱导活性似乎与其造血刺激活性不同，因为对LPS无反应的C3H/HeJ小鼠对LPS的前一种活性有反应。
To determine possible migratory responses to LPS of haemopoietic stem cells (CFUs) in LPS-nonresponsive (C3H/HeJ) mice, changes in the number of CFUs and granulocyte-macrophage progenitor cells (CFUc) after LPS-treatment where studied in splenectomized C3H/ HeJ mice. Splenectomy abrogated the decrease in bone marrow stem cells (CFUs and CFUc) induced by LPS in both LPS-responsive and nonresponsive mice. Recovery of bone marrow stem cells after irradiation was greatly enhanced by splenectomy in C3H/slc mice, but such enhancement was not observed in C3H/HeJ mice. These data suggest that the increase in the number of haemopoietic stem cells in the spleen in C3H/HeJ mice depends on the migration of haemopoietic stem cells from marrow to the spleen. Thus, the expansion of CFUs does not correlate with increase in the number of whole body haemopoietic stem cells. The migrationinducing activity of LPS seems to differ from its haemopoietic stimulatory activity, since the LPS-nonresponsive C3H/HeJ mice respond to the former activity of LPS.