MISCLASSIFICATION OF SMOKING STATUS BY SELF-REPORTED CIGARETTE CONSUMPTION
MISCLASSIFICATION OF SMOKING STATUS BY SELF-REPORTED CIGARETTE CONSUMPTION
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DOI：
10.1164/ajrccm/145.1.53
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发表时间：
1992-01-01
期刊：
影响因子：
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通讯作者：
BENOWITZ, NL
中科院分区：
文献类型：
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作者：
PEREZSTABLE, EJ;MARIN, G;BENOWITZ, NL
为了评估吸烟者和非吸烟者可能的错误分类，我们比较了743名西班牙裔健康和营养调查（HHANES）墨西哥裔美国人参与者的自我报告的香烟消费量和血清可替宁水平。研究样本按性别和自我报告的每日吸烟量（0、1 - 9、10 - 19和大于或等于20支）分层，并从有可用血清的样本中选择。我们将生化吸烟者定义为血清可替宁水平大于或等于0.084 μ M/L（14 ng/ml）的人。错误分类被定义为自我报告的吸烟与用于定义生化吸烟者的血清可替宁水平之间的差异。在189名自我报告的不吸烟者中，12名（6.3%）被定义为生化吸烟者，并可能被自我报告错误分类。在124名从不吸烟者中，只有5名（4%）是生化吸烟者，而65名自我报告的前吸烟者中有7名（10.8%）。在12名被错误分类的非吸烟者中，只有1人报告与当前吸烟者生活在一起。在9的12个错误分类的非吸烟者，血清可替宁水平与轻度吸烟一致。在547名自我报告的吸烟者中，发现66名（12.1%）血清可替宁水平小于或等于0.084 μ M/L（14 ng/ml），并可能被自我报告错误分类。其中，有一个人报告每天吸烟20支或更多。我们的结论是，自我报告的香烟消费量可能是一个不充分的措施与烟草使用和测量血清可替宁的风险可能是重要的，以评估在流行病学研究中的吸烟状态的错误分类的程度。
To evaluate possible misclassification of smokers and nonsmokers, we compared self-reported cigarette consumption and serum cotinine levels in a sample of 743 Mexican American participants in the Hispanic Health and Nutrition Examination Survey (HHANES). The study sample was stratified by sex and self-reported cigarettes consumed per day (0, 1 to 9, 10 to 19, and greater-than-or-equal-to 20) and selected from those with available serum. We defined biochemical smokers as persons with serum cotinine levels greater-than-or-equal-to 0.084-mu-M/L (14 ng/ml). Misclassification was defined as a discrepancy between self-reported smoking and the serum cotinine level used to define a biochemical smoker. Of 189 self-reported nonsmokers, 12 (6.3%) were defined as biochemical smokers and possibly misclassified by self-report. Among 124 never smokers only 5 (4%) were biochemical smokers compared with 7 of 65 (10.8%) self-reported former smokers. Only 1 of the 12 misclassified nonsmokers reported living with a current smoker. In 9 of the 12 misclassified nonsmokers, serum cotinine levels were consistent with light smoking. Among the 547 self-reported smokers, 66 (12.1%) were found to have serum cotinine levels less-than-or-equal-to 0.084-mu-M/L (14 ng/ml) and possibly misclassified by self-report. Of these, one person reported 20 or more cigarettes per day. We conclude that self-reported cigarette consumption may be an insufficient measure of the risks associated with tobacco use and measurement of serum cotinine may be important to assess the magnitude of misclassification of smoking status in epidemiologic studies.