TISSUE DISTRIBUTION OF PCB COMPONENTS IN SWINE AND SHEEP FED 3 DIFFERENT RATIONS CONTAINING AROCLORS 1242 AND 1254
TISSUE DISTRIBUTION OF PCB COMPONENTS IN SWINE AND SHEEP FED 3 DIFFERENT RATIONS CONTAINING AROCLORS 1242 AND 1254
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DOI：
10.1007/bf02220909
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发表时间：
1977-01-01
影响因子：
4
通讯作者：
METCALF, RL
中科院分区：
文献类型：
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作者：
HANSEN, LG;WELBORN, ME;METCALF, RL
生长猪和绵羊被饲喂三种不同的日粮，其中Aroclors 1242或1254的含量为20ppm，持续13至15周。一般来说，Aroclor 1254残留量较高；猪血、脾和卵巢中较高的1242残留量归因于该Aroclor的持久性主要成分。在不同的饲料中，总多氯联苯有一些细微的差异，但峰组成没有变化。一些氯化程度较低的成分在血液中保持了比其他成分更高的水平；其他成分选择性地积累在脂肪和肌肉等组织中。绵羊的血液和脂肪残留量在饲养的最后几周下降。在两个物种中，微粒体氧化酶水平都随着多氯联苯和饮食的增加而升高，但对绵羊的反应更大。羊肝微粒体能代谢Aroclor 1242的纯类似物和组分。Aroclor图谱在猪和羊的残留物中有很大差异，可以通过测量血液和背脂中选定的峰来估计总残留量。对多氯联苯总残留量提供最可靠估计的峰因物种和芳香族化合物而异。
Growing swine and sheep were fed three dietary variations containing 20 ppm of Aroclors 1242 or 1254 for 13 to 15 weeks. Generally, Aroclor 1254 residues were higher; higher 1242 residues in swine blood, spleen, and ovary are attributed to persistent major components of this Aroclor. Some minor differences in total PCB were observed with varying diets, but peak composition did not vary. Some lower chlorinated components maintained higher levels in the blood relative to other components; other components were selectively accumulated in tissues such as fat and muscle.Blood and fat residues in sheep declined during the last weeks of feeding. Microsomal oxidase levels were elevated in response to PCB and diet in both species, but the response was greater in sheep. Sheep liver microsomes were capable of metabolizing pure analogs and components of Aroclor 1242.Major differences in Aroclor profiles can be demonstrated between swine and sheep residues and total residues can be estimated by measuring selected peaks in blood and backfat. The peaks which provide the most reliable estimate of total PCB residue vary with species and Aroclor.