Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior
Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior
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DOI：
10.1016/s0893-133x(01)00408-0
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发表时间：
2002-06-01
影响因子：
7.6
通讯作者：
Hölter, SM
中科院分区：
文献类型：
--
作者：
Henniger, MSH;Spanagel, R;Hölter, SM
根据张力降低假说，ART焦虑水平升高的人可能对酒精的缓解焦虑作用更敏感，因此可能有更高的饮酒倾向。为了验证这一假设，我们研究了两个品系的大鼠的饮酒行为以及对酒精缓解焦虑效应的敏感性，这两个品系的饲养是为了在高架的正迷宫上寻找焦虑相关行为的差异：极度焦虑的HAB(高焦虑相关行为)和非焦虑的LAB(低焦虑相关行为)线。在自由选择的4瓶家笼范式中，研究了雌性和雄性HAB和实验室大鼠的酒精自我管理和酒精剥夺效应的发生。通过对HAB和LAB大鼠急性注射乙醇后的高架迷宫行为测试，评价了HAB和LAB大鼠对酒精抗焦虑作用的敏感性。在自愿饮酒的第一天，雌性实验鼠的酒精摄入量和偏好显著高于雌性实验鼠。尽管在统计学上没有显著意义，但在男性实验室中也可以看到同样的趋势。此外，雄性和雌性LAB大鼠在戒酒后都表现出显著的酒精剥夺效应，而HAB大鼠则没有。给予幼年动物糖精的结果没有差异，这表明HAB和LAB大鼠饮酒行为的不同并不代表新液体摄入量的总体差异。酒精对HAB大鼠有抗焦虑作用，但对实验大鼠无明显影响。综上所述，HAB大鼠与生俱来的焦虑与自愿饮酒有一定的相关性，但这种关系是负相关的。结论是，尽管这种关系骑士存在于解决问题的个体中，但与生俱来的焦虑水平和饮酒并不一定相关，(C)2002美国神经精神药理学学院。爱思唯尔科学公司出版。
According to the tension reduction hypothesis, individuals with art elevated anxiety level may be more sensitive to the anxiolytic effects of alcohol and may, therefore, have a higher predisposition to consume alcohol. To examine this hypothesis, we studied the drinking behavior as well as the sensitivity to the anxiolytic effect of alcohol in two rat lines that were bred and selected for differences in anxiety-related behavior on the elevated plus-maze: the extremely anxious HAB (high anxiety-related behavior) and the non-anxious LAB (low anxiety-related behavior) lines.Alcohol self-administration and the occurrence of an alcohol deprivation effect were studied in female and male HAB and LAB rats in a free-choice, 4-bottle home cage paradigm. The sensitivity of HAB and LAB rats to the anxiolytic effect of alcohol was assessed by testing their behavior oil the elevated plus-maze after an acute application of ethanol.During the first days of voluntary ethanol drinking, the ethanol intake and preference of female LABs was significantly higher than that of female HABs. Although not statistically significant, the same trend could be seen in male LABs. Moreover, male as well as female LAB but not HAB rats showed a significant alcohol deprivation effect after abstinence. There were no differences when saccharin was presented to naive animals, indicating that the different ethanol drinking behavior of HAB and LAB rats does not represent a general difference in the consumption of new liquids. Application of ethanol resulted in an anxiolytic effect in HAB but not in LAB rats oil the elevated plus-maze.In summary, increased inborn anxiety and voluntary ethanol consumption of HAB and LAB rats were correlated to some extent; however, this relationship was a negative one. It is concluded that, although such a relationship knight exist in solve individuals, increased levels of inborn anxiety and alcohol consumption are not necessarily related, (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.