Effect of progestins on implantation in the western spotted skunk.
Effect of progestins on implantation in the western spotted skunk.
复制标题
孕激素对西部斑点臭鼬着床的影响。
DOI：
10.1095/biolreprod25.1.128
复制
发表时间：
1981
影响因子：
3.6
通讯作者：
McRae,M
中科院分区：
文献类型：
--
作者：
Mead,RA;Concannon,PW;McRae,M
用孕酮胶囊或注射醋酸甲羟孕酮（MPA）对完整或切除卵巢的妊娠西方斑点臭鼬进行治疗在延迟着床的延长期内，以确定两种孕激素是否会缩短着床前时间。在给予外源性药物的完整臭鼬和卵巢切除臭鼬中，血浆孕激素升高至与先前在着床时观察到的水平非常相似的水平孕酮然而，该处理未能显著加速完整雌性动物的着床，并且在任何卵巢切除雌性动物中均未发生着床。Progressive在卵巢切除术后120天内维持囊胚活力相对有效。MPA治疗同样未能缩短植入前期，植入没有发生在任何卵巢切除MPA治疗的臭鼬。后一组动物的囊胚存活率降低。这些结果表明，增加孕酮分泌，这之前更新的胚泡发育和植入在这个物种中，是不是唯一的激素trier这些事件。
Intact or ovariectomized pregnant western spotted skunks were treated with progesterone administered in Silastic capsules or injected with medroxyprogesterone acetate (MPA) during the prolonged period of delayed implantation to determine whether either progestin would shorten the preimplantation period.Plasma progesterone was elevated to levels which closely mimicked those previously observed at the time of implantation in both intact and ovariectomized skunks administered exogenous progesterone. However, this treatment failed to hasten implantation significantly in intact females, and nidation did not occur in any of the ovariectomized females. Progesterone was relatively effective in maintaining blastocyst viability for 120 days after ovariectomy. Treatment with MPA likewise failed to shorten the preimplantation period, and implantation did not occur in any of the ovariectomized MPA-treated skunks. Blastocyst survival was diminished in the latter group of animals. These results indicate that increased progesterone secretion, which precedes renewed blastocyst development and implantation in this species, is not the sole hormonal trier of these events.