Radiofrequency ablation is a feasible therapeutic option in the multi modality management of sarcoma
Radiofrequency ablation is a feasible therapeutic option in the multi modality management of sarcoma
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DOI：
10.1016/j.ejso.2009.12.005
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发表时间：
2010-05-01
期刊：
影响因子：
3.8
通讯作者：
Judson, I. R.
中科院分区：
文献类型：
--
作者：
Jones, R. L.;McCall, J.;Judson, I. R.
射频消融 (RFA) 在转移性肉瘤中的作用尚不明确。本研究的目的是评估 RFA 对一系列肉瘤患者的疗效和安全性。对前瞻性维护的数据库进行回顾性搜索，确定了 13 名胃肠道间质瘤 (GIST) 患者和 12 名接受 RFA 治疗的其他组织学亚型患者。所有 GIST 患者均因肝脏转移性疾病接受 RFA：其中 12 例对第一次 RFA 手术有反应，1 例病情稳定。两名 GIST 患者两次接受 RFA 来分离肝脏内的病灶，并且都对第二次 RFA 手术有反应。在其他亚型中：7 例接受了针对肝脏病变的 RFA，其中 5 例对 RFA 有反应，1 例病情进展，在分析时无法评估我的反应。所有 5 名肺转移患者在第一次 RFA 手术后均获得缓解。 RFA 在这一系列肉瘤患者中有效且耐受性良好。 RFA 可能对单一转移进展但其他部位疾病稳定的 GIST 患者发挥作用。需要进一步更大规模的研究来更好地确定该技术在该患者群体中的作用。 (C) 2010 Elsevier Ltd. 保留所有权利。
The role of radiofrequency ablation (RFA) in metastatic sarcoma is not well defined. The aim of this study was to evaluate the efficacy and safety of RFA in a series of sarcoma patients. A retrospective search of a prospectively maintained database identified 13 gastrointestinal stromal tumour (GIST) patients and 12 with other histological subtypes treated with RFA. All the GIST patients received RFA for metastatic disease in the liver: 12 of these responded to the first RFA procedure and one achieved stable disease. Two GIST patients received RFA on two occasions to separate lesions within the liver and both responded to the second RFA procedure. Of the other subtypes: 7 underwent RFA to liver lesions, 5 of these responded to RFA, one progressed and I was not assessable for response at the time of analysis. All 5 patients with lung metastases achieved a response following their first RFA procedure. RFA was effective and well tolerated in this series of sarcoma patients. RFA may have a role in patients with GIST who have progression in a single metastasis but stable disease elsewhere. Further larger studies are required to better define the role of this technique in this patient population. (C) 2010 Elsevier Ltd. All rights reserved.