Physiological simulation of blood flow in the aorta: Comparison of hemodynamic indices as predicted by 3-D FSI, 3-D rigid wall and 1-D models
Physiological simulation of blood flow in the aorta: Comparison of hemodynamic indices as predicted by 3-D FSI, 3-D rigid wall and 1-D models
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DOI：
10.1016/j.medengphy.2012.08.009
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发表时间：
2013-06-01
影响因子：
2.2
通讯作者：
Stergiopulos, Nikos
中科院分区：
文献类型：
--
作者：
Reymond, Philippe;Crosetto, Paolo;Stergiopulos, Nikos
近年来，对患者特定血流循环建模的兴趣大幅增加。几何和弹性特性的临床数据的可用性以及有效的数值方法现在已经使模型渲染成为可能。这项工作使用3-D流体-结构相互作用（FSI），以提供生理模拟，从而在建模与高层次的细节。使用FSI和刚性壁模型的结果进行了比较。壁顺应性的相关性，在确定参数的临床意义，如壁剪切应力，一起讨论的压力和流量波形中发现的差异的意义时，使用1-D model. Patient特定的几何形状的主动脉及其分支的MRI血管造影数据的基础上。动脉壁的厚度是可变的。流体域的边界条件是升主动脉处的压力波形和每个出口的流量。使用1-D模型获得的波形，该模型通过对同一人进行的体内测量进行验证。为了模拟周围组织的力学效应，将应力-位移关系应用于动脉壁，给出了主动脉弓和胸主动脉壁面剪应力的时间变化和空间分布，以及刚性壁模型和FSI模型的差异。3-D模拟的1-D模型的比较显示出良好的再现的压力和流量波形。(C)2012年IPEM。由爱思唯尔有限公司出版。保留所有权利。
Interest in patient-specific blood-flow circulation modeling has increased substantially in recent years. The availability of clinical data for geometric and elastic properties together with efficient numerical methods has now made model rendering feasible. This work uses 3-D fluid-structure interaction (FSI) to provide physiological simulation resulting in modeling with a high level of detail. Comparisons are made between results using FSI and rigid wall models. The relevance of wall compliance in determining parameters of clinical importance, such as wall shear stress, is discussed together with the significance of differences found in the pressure and flow waveforms when using the 1-D model.Patient-specific geometry of the aorta and its branches was based on MRI angiography data. The arterial wall was created with a variable thickness. The boundary conditions for the fluid domain were pressure waveform at the ascending aorta and flow for each outlet. The waveforms were obtained using a 1-D model validated by in vivo measurements performed on the same person. In order to mimic the mechanical effect of surrounding tissues in the simulation, a stress-displacement relation was applied to the arterial wall.The temporal variation and spatial patterns of wall shear stress are presented in the aortic arch and thoracic aorta together with differences using rigid wall and FSI models. A comparison of the 3-D simulations to the 1-D model shows good reproduction of the pressure and flow waveforms. (C) 2012 IPEM. Published by Elsevier Ltd. All rights reserved.