Etiology and pediatric chronic kidney disease progression: Taiwan Pediatric Renal Collaborative Study
Etiology and pediatric chronic kidney disease progression: Taiwan Pediatric Renal Collaborative Study
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DOI：
10.1016/j.jfma.2015.07.019
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发表时间：
2016-09-01
影响因子：
3.2
通讯作者：
Chou, Hsin-Hsu
中科院分区：
文献类型：
--
作者：
Chiou, Yuan-Yow;Lin, Ching-Yuang;Chou, Hsin-Hsu
背景/目的：本研究旨在探讨台湾慢性肾脏病(CKD)儿童的特征及疾病进展的因素。方法：我们回顾了台湾儿童慢性肾脏病(CKD)多中心数据库“台湾儿科肾脏合作研究”的记录。结果：共纳入382名1~18岁儿童，中位年龄10.6岁，四分位数范围6.4~13.8岁。男性197人(51.6%)，女性185人。CKD 1期159例(41.6%)，2期160例(41.9%)，3期51例(13.4%)，4期12例(3.1%)。56名儿童(14.7%)经历了CKD进展。对所有患者的多变量分析表明，继发于结构异常、遗传病、贫血、舒张压升高或血尿素氮升高的CKD儿童疾病进展的风险增加。与1期CKD儿童相比，在短期队列随访中，2期和4期CKD儿童CKD进展的风险降低。结论：CKD病因影响疾病进展。仔细监测和治疗慢性肾脏病儿童的贫血和血压升高可能会减缓疾病的进展。版权所有(C)2015，台湾医学会。爱思唯尔台湾有限责任公司出版。这是一篇CC BY-NC-ND许可证下的开放获取文章。
Background/Purpose: This study aims to examine the characteristics of Taiwanese children with chronic kidney disease (CKD) and delineate the factors that lead to disease progression in this population.Methods: We reviewed the records of the Taiwan Pediatric Renal Collaborative Study, a multicenter database of Taiwanese children with CKD. Multivariate regression analysis was used to identify the main factors associated with disease progression.Results: A total of 382 children aged 1-18 years were included in the study (median age was 10.6 years; interquartile range: 6.4-13.8). There were 197 males (51.6%) and 185 females. CKD Stage 1 was diagnosed in 159 children (41.6%), Stage 2 in 160 (41.9%), Stage 3 in 51 (13.4%), and Stage 4 in 12 (3.1%). Fifty-six children (14.7%) experienced CKD progression. A multivariate analysis for all patients indicated that the risk for disease progression was increased in children with CKD secondary to a structural abnormality, genetic disease, anemia, elevated diastolic blood pressure, or elevated blood urea nitrogen. Compared with children with Stage 1 CKD, those with Stage 2 and Stage 4 CKD had decreased risk for CKD progression in this shortterm cohort follow-up.Conclusion: CKD etiology affects disease progression. Careful monitoring and treatment of anemia and elevated blood pressure in children with CKD may slow disease progression. Copyright (C) 2015, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.