Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3':5'-monophosphate, and induction of mouse skin tumors in vivo.
Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3':5'-monophosphate, and induction of mouse skin tumors in vivo.
复制标题
12-O-十四烷酰佛波醇-13-乙酸酯和 mezerein 对表皮鸟氨酸脱羧酶活性、异丙肾上腺素刺激的环腺苷 3:5-单磷酸水平以及体内小鼠皮肤肿瘤诱导的影响。
作者：
Mufson Ra;S. Fischer;Verma Ak;G. Gleason;T. Slaga;R. Boutwell
肿瘤促进剂12-O-十四酰基佛波醇-13-乙酸酯和抗白血病剂美泽瑞因是植物来源的二萜酯，具有某些结构相似性。当局部应用于小鼠皮肤时，两种化合物在诱导增生、炎症和鸟氨酸脱羧酶活性以及减少响应于β-肾上腺素能刺激的环腺苷3 '：5'-单磷酸积累方面在摩尔基础上是等效的。相比之下，美泽瑞因作为肿瘤促进剂的有效性要低得多;对于类似启动的SENCAR小鼠，8.5 nmol/应用的佛波醇酯产生的肿瘤是8.5 nmol/应用的美泽瑞因的78倍。佛波醇酯的优越性在CD-1小鼠中几乎一样大。
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the antileukemic agent mezerein are diterpene esters of plant origin with certain structural similarities. Both compounds, when applied topically to mouse skin, were equipotent on a molar basis in inducing hyperplasia, inflammation, and ornithine decarboxylase activity, as well as in reducing cyclic adenosine 3':5'-monophosphate accumulation in response to beta-adrenergic stimulation. In contrast, mezerein was much less effective as a tumor promoter; the phorbol ester at 8.5 nmol/application yielded 78-fold more tumors than did 8.5 nmol mezerein per application to similarly initiated SENCAR mice. The superiority of the phorbol ester was nearly as great in CD-1 mice.
通过重复 12-o-十四烷酰佛波醇-13-乙酸酯处理来超诱导小鼠表皮鸟氨酸脱羧酶活性。
影响因子：
4.3
作者：
Verma,AK;Hsiao,KM;Ahrens,H;Suganuma,M;Fujiki,H;Matsufuji,S;Hayashi,H
通讯作者：
Hayashi,H