Effect of oxidative stress on male reproduction.
Effect of oxidative stress on male reproduction.
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DOI：
10.5534/wjmh.2014.32.1.1
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
du Plessis SS
中科院分区：
文献类型：
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作者：
Agarwal A;Virk G;Ong C;du Plessis SS
不孕症影响了大约15%的试图怀孕的夫妇，男性因素导致了大约一半的病例。氧化应激（Oxidative stress，OS）是导致精子功能障碍的重要因素之一。OS是一种与由氧和氧衍生的自由基（称为活性氧物质（ROS））引发的细胞损伤增加相关的状态。在这个过程中，ROS的增加破坏了身体的抗氧化防御。虽然精子的正常功能需要少量的活性氧，但不成比例的水平会对精子的质量产生负面影响并损害其整体受精能力。OS已被确定为一个非常关注的领域，因为ROS及其代谢产物可以攻击DNA，脂质和蛋白质;改变酶系统;产生不可修复的改变;导致细胞死亡;并最终导致与男性不育相关的精液参数下降。这篇综述强调了ROS产生的机制，ROS在男性生殖系统中的生理和病理生理作用，以及诊断方法的最新进展;它还探讨了在临床环境中使用抗氧化剂的好处。
Infertility affects approximately 15% of couples trying to conceive, and a male factor contributes to roughly half of these cases. Oxidative stress (OS) has been identified as one of the many mediators of male infertility by causing sperm dysfunction. OS is a state related to increased cellular damage triggered by oxygen and oxygen-derived free radicals known as reactive oxygen species (ROS). During this process, augmented production of ROS overwhelms the body's antioxidant defenses. While small amounts of ROS are required for normal sperm functioning, disproportionate levels can negatively impact the quality of spermatozoa and impair their overall fertilizing capacity. OS has been identified as an area of great attention because ROS and their metabolites can attack DNA, lipids, and proteins; alter enzymatic systems; produce irreparable alterations; cause cell death; and ultimately, lead to a decline in the semen parameters associated with male infertility. This review highlights the mechanisms of ROS production, the physiological and pathophysiological roles of ROS in relation to the male reproductive system, and recent advances in diagnostic methods; it also explores the benefits of using antioxidants in a clinical setting.