Role of metabolism and viruses in aflatoxin-induced liver cancer
Role of metabolism and viruses in aflatoxin-induced liver cancer
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DOI：
10.1016/j.taap.2004.09.020
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发表时间：
2005-08-07
影响因子：
3.8
通讯作者：
Kensler, TW
中科院分区：
文献类型：
--
作者：
Groopman, JD;Kensler, TW
在分子流行病学研究中使用生物标志物来识别环境因素对健康影响的发展阶段，有可能为关键的监管、临床和公共卫生问题提供重要信息。黄曲霉毒素的研究可能代表了该领域最广泛的数据集之一，这项工作可以作为其他环境因素未来研究的模板。黄曲霉毒素是天然存在的霉菌毒素，存在于玉米、花生、各种其他坚果和棉籽等食品中，在许多实验模型中已被证明具有致癌性。经过近30年的研究、实验数据和人群流行病学研究，黄曲霉毒素B-1被国际癌症研究机构列为人类致癌物。本文所述研究的长期目标是将生物标志物应用于开发预防性干预措施，用于癌症高危人群。几种黄曲霉毒素特异性生物标志物已在流行病学研究中得到验证，目前被用作预防研究中的中间生物标志物。这些黄曲霉毒素生物标志物的开发基于从实验和人体研究中收集的黄曲霉毒素生物化学和毒理学知识。这些生物标志物随后被用于实验模型中，以提供在不同疾病风险情况下这些标志物的调节数据。这种系统方法为预防性干预措施提供了鼓励，并应作为开发、验证和应用其他癌症或其他慢性疾病化学特异性生物标志物的模板。 (c) 2005 年，爱思唯尔公司出版。
The use of biomarkers in molecular epidemiology studies for identifying stages in the progression of development of the health effects of environmental agents has the potential for providing important information for critical regulatory, clinical and public health problems. Investigations of aflatoxins probably represent one of the most extensive data sets in the field and this work may serve as a template for future studies of other environmental agents. The aflatoxins are naturally occurring mycotoxins found on foods such as corn, peanuts, various other nuts and cottonseed and they have been demonstrated to be carcinogenic in many experimental models. As a result of nearly 30 years of study, experimental data and epidemiological studies in human populations, aflatoxin B-1 was classified as carcinogenic to humans by the International Agency for Research on Cancer. The long-term goal of the research described herein is the application of biomarkers to the development of preventative interventions for use in human populations at high-risk for cancer. Several of the aflatoxin-specific biomarkers have been validated in epidemiological studies and are now being used as intermediate biomarkers in prevention studies. The development of these aflatoxin biomarkers has been based upon the knowledge of the biochemistry and toxicology of aflatoxins gleaned from both experimental and human studies. These biomarkers have subsequently been utilized in experimental models to provide data on the modulation of these markers under different situations of disease risk. This systematic approach provides encouragement for preventive interventions and should serve as a template for the development, validation and application of other chemical-specific biomarkers to cancer or other chronic diseases. (c) 2005 Published by Elsevier Inc.