Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis - The Vitamin E Atherosclerosis Prevention Study (VEAPS)
Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis - The Vitamin E Atherosclerosis Prevention Study (VEAPS)
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DOI：
10.1161/01.cir.0000029092.99946.08
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发表时间：
2002-09-17
期刊：
影响因子：
37.8
通讯作者：
Azen, SP
中科院分区：
文献类型：
--
作者：
Hodis, HN;Mack, WJ;Azen, SP
流行病学研究表明，维生素E摄入量与心血管疾病（CVD）风险呈负相关。相比之下，关于补充维生素E是否能减少动脉粥样硬化进展和心血管疾病事件，随机对照试验报告了相互矛盾的结果。方法与结果：研究人群为年龄≥40岁、LDL胆固醇水平≥3.37 mmol/L （130 mg/dL）、无CVD临床体征或症状的男性和女性。符合条件的参与者被随机分配到每天400 IU的dl - α -生育酚组或安慰剂组，每3个月随访一次，平均随访3年。主要试验终点是通过计算机图像处理b超评估颈总动脉远壁内膜-中膜厚度（IMT）的变化率。一个混合效应模型使用所有的IMT的决定来检验假设的治疗差异的IMT变化率。与安慰剂相比，补充α -生育酚可显著提高血浆维生素E水平(P
Background-Epidemiological studies have demonstrated an inverse relationship between vitamin E intake and cardiovascular disease (CVD) risk. In contrast, randomized controlled trials have reported conflicting results as to whether vitamin E supplementation reduces atherosclerosis progression and CVD events.Methods and Results-The study population consisted of men and women greater than or equal to40 years old with an LDL cholesterol level greater than or equal to3.37 mmol/L (130 mg/dL) and no clinical signs or symptoms of CVD. Eligible participants were randomized to DL-alpha-tocopherol 400 IU per day or placebo and followed every 3 months for an average of 3 years. The primary trial end point was the rate of change in the common carotid artery far-wall intima-media thickness (IMT) assessed by computer image-processed B-mode ultrasonograms. A mixed effects model using all determinations of IMT was used to test the hypothesis of treatment differences in IMT change rates. Compared with placebo, alpha-tocopherol supplementation significantly raised plasma vitamin E levels (P