Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort
Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort
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DOI：
10.1002/alz.12632
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发表时间：
2022-03-30
影响因子：
14
通讯作者：
Binns, Malcolm A.
中科院分区：
文献类型：
--
作者：
Sunderland, Kelly M.;Beaton, Derek;Binns, Malcolm A.
引言了解改变痴呆症表现的神经退行性疾病和脑血管病理之间的协同作用代表了一个重要的知识差距。方法这项多中心、纵向、观察性队列研究招募了流行的神经退行性疾病和脑血管疾病的参与者，并对参与者进行了全面的评估。我们描述了队列的单变量和多变量基线特征，并总结了招募，数据收集和策展过程。结果我们招募了520名参与者，涉及五种神经退行性疾病和脑血管疾病。中位年龄为69岁，蒙特利尔认知评估评分中位数为25，日常生活活动的独立性中位数为100%（基本活动）和93%（工具活动）。配偶研究伙伴占主导地位;参与者往往是男性，白色，更受过教育。轻度疾病阶段占主导地位，但队列反映临床表现。数据将与全球科学界共享。疾病内和疾病不可知的方法预计将确定严重程度，进展和治疗目标的标志物。采样特征也为未来的研究设计提供了指导。
Introduction Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods This multi-site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes. Results We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation. Discussion Data will be shared with the global scientific community. Within-disease and disease-agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.