Chemical and biochemical aspects of superoxide radicals and related species of activated oxygen.
Chemical and biochemical aspects of superoxide radicals and related species of activated oxygen.
复制标题
超氧自由基和相关活性氧种类的化学和生化方面。
DOI：
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发表时间：
1982
影响因子：
2.1
通讯作者：
A. Singh
中科院分区：
文献类型：
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作者：
A. Singh
生命系统利用氧的生物过程范围相当大，其产物包括一些活性氧的破坏性物质，特别是超氧自由基（O2-）和过氧化氢（H2 O2）。超氧化物自由基和过氧化氢，反过来，可以导致其他有害物质的形成：羟基自由基（.OH）和单线态氧（1 O2）。羟基自由基与有机化合物反应生成二级自由基，二级自由基在氧存在下生成过氧自由基、过氧化物和氢过氧化物。形成，相互转换，和反应性的O-.2和相关的活性氧物种，可用于检测的方法，其生物毒性的基础进行了简要的回顾。
The spectrum of biological processes in which oxygen is used by living systems is quite large, and the products include some damaging species of activated oxygen, particularly the superoxide radical (O-.2) and hydrogen peroxide (H2O2). Superoxide radicals and hydrogen peroxide, in turn, can lead to the formation of other damaging species: hydroxyl radicals (.OH) and singlet oxygen (1O2). Hydroxyl radicals react with organic compounds to give secondary free radicals that, in the presence of oxygen, yield peroxy radicals, peroxides, and hydroperoxides. Formation, interconversion, and reactivity of O-.2 and related activated oxygen species, methods available for their detection, and the basis of their biological toxicity are briefly reviewed.