Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
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DOI：
10.1038/ni.1724
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发表时间：
2009-05-01
影响因子：
30.5
通讯作者：
Heath, William R.
中科院分区：
文献类型：
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作者：
Bedoui, Sammy;Whitney, Paul G.;Heath, William R.
皮肤来源的树突状细胞(DC)包括朗格汉斯细胞、经典真皮DC和CD103(+)阳性真皮细胞亚群。我们研究了它们在皮肤相关病毒和自身抗原的呈递过程中的作用。只有CD103(+)亚群有效地将单纯疱疹病毒1型抗原呈递给初治的CD8(+)T细胞，尽管所有亚群都将这些抗原呈递给CD4(+)T细胞。这表明CD103+DC是最有效地将病毒抗原处理成主要组织相容性复合体I类途径的迁移亚群，可能是通过交叉递呈。数据显示，只有CD103(+)DC有效地交叉提呈皮肤来源的自身抗原，这一点得到了支持。这表明CD103(+)DC是能够交叉呈递病毒和自身抗原的主要迁移亚型，这表明皮肤DC具有另一种特化水平。
Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103(+) subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8(+) T cells, although all subsets presented these antigens to CD4(+) T cells. This showed that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103(+) DCs efficiently cross-presented skin-derived self antigens. This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs.