Improving source reconstructions by combining bioelectric and biomagnetic data
Improving source reconstructions by combining bioelectric and biomagnetic data
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DOI：
10.1016/s0013-4694(98)00046-7
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发表时间：
1998-08-01
期刊：
影响因子：
--
通讯作者：
Buchner, H
中科院分区：
文献类型：
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作者：
Fuchs, M;Wagner, M;Buchner, H
目标：提出了一个结合生物电和生物磁数据的框架。数据被转换为信噪比，并引入了利用新的正则化方法的重建算法。方法：对 19 个不同的 EEG 和 MEG 蒙太奇进行了广泛的模拟，其中径向和切向测试偶极子处于不同的偏心率和噪声水平。这些方法通过真实的 SEP/SEE 测量进行验证。使用常见的现实体积导体，并且通过校准磁数据来匹配不太为人所知的体内电导率。提出了单一等效偶极子拟合以及时空源模型，用于单一和组合模态评估，并叠加到解剖 MR 图像上。结果：不同 EEG/MEG 采集系统的归一化灵敏度和偶极子分辨率配置文件是从模拟数据得出的。这些方法和模拟通过同时测量的体感数据进行了验证。结论：揭示了组合数据研究的卓越空间分辨率，这是由于两种模式的互补性和传感器数量的增加所致。由于可以改进准切向源和准径向源之间的区分，因此可以更好地理解潜在的神经元过程。 (C) 1998 Elsevier Science Ireland Ltd. 保留所有权利。
Objectives: A framework for combining bioelectric and biomagnetic data is presented. The data are transformed to signal-to-noise ratios and reconstruction algorithms utilizing a new regularization approach are introduced.Methods: Extensive simulations are carried out for 19 different EEG and MEG montages with radial and tangential test dipoles at different eccentricities and noise levels. The methods are verified by real SEP/SEE measurements. A common realistic volume conductor is used and the less well known in vivo conductivies are matched by calibration to the magnetic data. Single equivalent dipole fits as well as spatio-temporal source models are presented for single and combined modality evaluations and overlaid to anatomic MR images.Results: Normalized sensitivity and dipole resolution profiles of the different EEG/MEG acquisition systems are derived from the simulated data. The methods and simulations are verified by simultaneously measured somatosensory data.Conclusions: Superior spatial resolution of the combined data studies is revealed, which is due to the complementary nature of both modalities and the increased number of sensors. A better understanding of the underlying neuronal processes can be achieved, since an improved differentiation between quasi-tangential and quasi-radial sources is possible. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.