Frequency-dependent changes in local intrinsic oscillations in chronic primary insomnia: A study of the amplitude of low-frequency fluctuations in the resting state.
Frequency-dependent changes in local intrinsic oscillations in chronic primary insomnia: A study of the amplitude of low-frequency fluctuations in the resting state.
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慢性原发性失眠局部固有振荡的频率依赖性变化：静息状态下低频波动幅度的研究
DOI：
10.1016/j.nicl.2016.05.011
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Gong H
中科院分区：
文献类型：
--
作者：
Zhou F;Huang S;Zhuang Y;Gao L;Gong H
新的神经影像学技术使我们对原发性失眠的大脑机制的理解取得了重大进展。然而，神经元的低频振荡在慢性原发性失眠症（CPI）中仍然很大程度上没有特征。在这项研究中，低频波动幅度（ALFF），一种基于静息态功能磁共振成像的数据驱动方法，被用来检查27例CPI患者和27名年龄，性别和教育相匹配的健康对照的局部内在活动。我们研究了两个频带中的神经活动，慢-4（0.027和0.073 Hz之间）和慢-5（0.010-0.027 Hz），因为血氧水平依赖（BOLD）波动在不同的低频带可能会出现不同的神经生理学表现，属于时空组织。与原发疾病效应相关的ALFF广泛分布于小脑后叶（CPL）、背侧和腹侧前额叶皮质、前扣带皮质、楔前叶、体感皮质和几个默认模式子区域。几个大脑区域（即，右小脑、前叶和左壳核）显示频带和患者组之间的相互作用。在Slow-5频段，右侧中央后回/顶下小叶（PoCG/IPL）的ALFF增加与CPI患者的睡眠质量（ρ = 0.414，P = 0.044）和焦虑指数（ρ = 0.406，P = 0.049）相关。这些结果表明，在慢性失眠症，内在的功能可塑性主要是响应于过度觉醒状态，这是在感觉信息处理的抑制的损失。我们的研究结果异常的感觉输入和内在的处理机制可能提供新的见解CPI的病理生理。此外，在探讨ALFF相关临床表现时，应考虑频率因素。慢性原发性失眠症（CPI）患者的原发病效应广泛分布于多个脑区。几个大脑区域（即，右小脑、前叶和左壳核）表现出频带和患者组之间的相互作用。在慢5波段，增加的ALFF与CPI患者的睡眠质量或焦虑指数相关。我们的研究结果异常的感觉输入和内在的处理机制可能提供新的见解CPI的病理生理。此外，在探讨ALFF相关临床表现时，应考虑频率因素。
New neuroimaging techniques have led to significant advancements in our understanding of cerebral mechanisms of primary insomnia. However, the neuronal low-frequency oscillation remains largely uncharacterized in chronic primary insomnia (CPI). In this study, the amplitude of low-frequency fluctuation (ALFF), a data-driven method based on resting-state functional MRI, was used to examine local intrinsic activity in 27 patients with CPI and 27 age-, sex-, and education-matched healthy controls. We examined neural activity in two frequency bands, slow-4 (between 0.027 and 0.073 Hz) and slow-5 (0.010–0.027 Hz), because blood-oxygen level dependent (BOLD) fluctuations in different low-frequency bands may present different neurophysiological manifestations that pertain to a spatiotemporal organization. The ALFF associated with the primary disease effect was widely distributed in the cerebellum posterior lobe (CPL), dorsal and ventral prefrontal cortex, anterior cingulate cortex, precuneus, somatosensory cortex, and several default-mode sub-regions. Several brain regions (i.e., the right cerebellum, anterior lobe, and left putamen) exhibited an interaction between the frequency band and patient group. In the slow-5 band, increased ALFF of the right postcentral gyrus/inferior parietal lobule (PoCG/IPL) was enhanced in association with the sleep quality (ρ = 0.414, P = 0.044) and anxiety index (ρ = 0.406, P = 0.049) of the CPI patients. These findings suggest that during chronic insomnia, the intrinsic functional plasticity primarily responds to the hyperarousal state, which is the loss of inhibition in sensory-informational processing. Our findings regarding an abnormal sensory input and intrinsic processing mechanism might provide novel insight into the pathophysiology of CPI. Furthermore, the frequency factor should be taken into consideration when exploring ALFF-related clinical manifestations. Primary disease effect was widely distributed in several cerebral areas in patients with chronic primary insomnia (CPI). Several brain regions (i.e., right cerebellum, anterior lobe, and left putamen) exhibited interactions between the frequency band and patient group. In the slow-5 band, increased ALFF associated with the sleep quality or the anxiety index in the CPI patients. Our findings regarding an abnormal sensory input and intrinsic processing mechanism might provide novel insight into the pathophysiology of CPI. Furthermore, the frequency factor should be taken into consideration when exploring ALFF-related clinical manifestations.