Air pollution and development of asthma, allergy and infections in a birth cohort
Air pollution and development of asthma, allergy and infections in a birth cohort
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DOI：
10.1183/09031936.00083406
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发表时间：
2007-05-01
影响因子：
24.3
通讯作者：
Brunekreef, B.
中科院分区：
文献类型：
--
作者：
Brauer, M.;Hoek, G.;Brunekreef, B.
很少有研究涉及与交通有关的空气污染与幼儿呼吸道疾病之间的关系。本文作者在一项出生队列研究中评估了出生后4年内哮喘/过敏症状和呼吸道感染的发展情况（n= 4,000）。使用土地使用回归模型将与交通相关的空气污染物（二氧化氮PM2.5、50%截止空气动力学直径为2.5 μ m的颗粒物和煤烟）的室外浓度分配给出生地家庭地址。通过logistic回归分析，将其与医生诊断的哮喘、支气管炎、流感和湿疹的问卷数据以及自我报告的喘息、夜间干咳、耳/鼻/喉感染和皮疹联系起来。在一个亚组（n=713）中测量了常见过敏原的总免疫球蛋白（IG）E和特异性免疫球蛋白（Ig）E。（95%置信区间）每四分位数的污染范围升高喘息（煤烟为1.2（1.0-1.4））、医生诊断的哮喘（1.3（1.0-1.7））、耳/鼻/喉感染（1.2（1.0-1.3））和流感/严重感冒（1.2（1.0-1.4））。其他终点未观察到一致的相关性。空气污染与常见食物过敏原的特异性致敏性（煤烟为1.6（1.2-2.2））之间存在正相关，但在IgE测量的亚组中，总IgE与空气污染无关。
Few studies have addressed associations between traffic-related air pollution and respiratory disease in young children. The present authors assessed the development of asthmatic/allergic symptoms and respiratory infections during the first 4 yrs of life in a birth cohort study (n=similar to 4,000).Outdoor concentrations of traffic-related air pollutants (nitrogen dioxide PM2.5, particles with a 50% cut-off aerodynamic diameter of 2.5 mu m and soot) were assigned to birthplace home addresses with a land-use regression model. They were linked by logistic regression to questionnaire data on doctor-diagnosed asthma, bronchitis, influenza and eczema and to self-reported wheeze, dry night-time cough, ear/nose/throat infections and skin rash. Total and specific immunoglobulin (Ig)E to common allergens were measured in a subgroup (n=713).Adjusted odds ratios (95% confidence intervals) per interquartile pollution range were elevated for wheeze (1.2 (1.0-1.4) for soot), doctor-diagnosed asthma (1.3 (1.0-1.7)), ear/nose/throat infections (1.2 (1.0-1.3)) and flu/serious colds (1.2 (1.0-1.4)). No consistent associations were observed for other end-points. Positive associations between air pollution and specific sensitisation to common food allergens (1.6 (1.2-2.2) for soot), but not total IgE, were found in the subgroup with IgE measurements.Traffic-related pollution was associated with respiratory infections and some measures of asthma and allergy during the first 4 yrs of life.