The glymphatic system and subarachnoid hemorrhage: disruption and recovery.
The glymphatic system and subarachnoid hemorrhage: disruption and recovery.
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DOI：
10.37349/ent.2022.00023
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发表时间：
2022-01-01
期刊：
影响因子：
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通讯作者：
Lucke-Wold, Brandon
中科院分区：
文献类型：
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作者：
Quintin, Stephan;Barpujari, Arnav;Lucke-Wold, Brandon
淋巴系统，或神经胶质淋巴系统，是一个废物清除系统，由星形胶质细胞形成的血管周围通道组成，介导蛋白质和代谢物从大脑中的清除。这些通道促进了脑脊液在脑实质中的运动，对体内平衡至关重要。淋巴系统的破坏会导致这些废物的堆积，以及大脑中间质液体的增加。这些现象在蛛网膜下腔出血(SAH)期间和之后也可见，导致大血管破裂后的脑损伤。本文对SAH后淋巴系统的破坏及其在恢复中的作用作一综述。该综述还概述了针对淋巴系统的药物，并可能在SAH后应用于治疗。
The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the brain. These channels facilitate the movement of cerebrospinal fluid throughout brain parenchyma and are critical for homeostasis. Disruption of the glymphatic system leads to an accumulation of these waste products as well as increased interstitial fluid in the brain. These phenomena are also seen during and after subarachnoid hemorrhages (SAH), contributing to the brain damage seen after rupture of a major blood vessel. Herein this review provides an overview of the glymphatic system, its disruption during SAH, and its function in recovery following SAH. The review also outlines drugs which target the glymphatic system and may have therapeutic applications following SAH.