Prenylation of benzoic acid derivatives catalyzed by a transferase from Escherichia coli overproduction: Method development and substrate specificity
Prenylation of benzoic acid derivatives catalyzed by a transferase from Escherichia coli overproduction: Method development and substrate specificity
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DOI：
10.1002/anie.199616971
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发表时间：
1996-08-19
期刊：
影响因子：
--
通讯作者：
Sontag, B
中科院分区：
文献类型：
--
作者：
Wessjohann, L;Sontag, B
The enzymatic Friedel–Crafts alkylation for the synthesis of up to fivefold ring‐substituted 3‐polyprenylbenzoic acid derivatives can be accomplished regiospecifically with a polyprenyl‐transferase, which exhibits a surprisingly broad substrate spectrum ([Eq.(a)]; OPP= pyrophosphate). Although a membrane enzyme, its simple production and enrichment, and good shelf life provide an excellent basis for general use in organic synthesis.
