Travelling-wave analysis of a model of tumour invasion with degenerate, cross-dependent diffusion.

Travelling-wave analysis of a model of tumour invasion with degenerate, cross-dependent diffusion.
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DOI:
10.1098/rspa.2021.0593
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发表时间:
2021-12
期刊:
Proceedings. Mathematical, physical, and engineering sciences
影响因子:
--
通讯作者:
Lorenzi T
Lorenzi T
中科院分区:
其他
文献类型:
--
作者:
Colson C;Sánchez-Garduño F;Byrne HM;Maini PK;Lorenzi T

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In this paper, we carry out a travelling-wave analysis of a model of tumour invasion with degenerate, cross-dependent diffusion. We consider two types of invasive fronts of tumour tissue into extracellular matrix (ECM), which represents healthy tissue. These types differ according to whether the density of ECM far ahead of the wave front is maximal or not. In the former case, we use a shooting argument to prove that there exists a unique travelling-wave solution for any positive propagation speed. In the latter case, we further develop this argument to prove that there exists a unique travelling-wave solution for any propagation speed greater than or equal to a strictly positive minimal wave speed. Using a combination of analytical and numerical results, we conjecture that the minimal wave speed depends monotonically on the degradation rate of ECM by tumour cells and the ECM density far ahead of the front.
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