Large Relaxivity Enhancement of Paramagnetic Lipid Nanoparticles by Restricting the Local Motions of the GdIII Chelates
Large Relaxivity Enhancement of Paramagnetic Lipid Nanoparticles by Restricting the Local Motions of the GdIII Chelates
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DOI：
10.1021/ja101518v
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发表时间：
2010-06-16
影响因子：
15
通讯作者：
Botta, Mauro
中科院分区：
文献类型：
--
作者：
Kielar, Filip;Tei, Lorenzo;Botta, Mauro
设计、合成了一种在相邻的乙酸臂上带有两个脂肪链的Gd-III-DOTA类配合物，并与其类似的单官能化配合物进行了比较。一个1/T-1核磁共振弛豫研究的两个两亲性配合物纳入胶束和脂质体显示了前所未有的弛豫增强与两个亲脂性侧臂的配合物。这一显著的结果，这是由于一个有利的水交换率和增加的系统的刚性所造成的限制的钆中心的局部运动，代表了一个重要的进展，在开发高效的纳米系统的MRI应用。
A Gd-III-DOTA-like complex bearing two aliphatic chains on adjacent acetic arms was designed, synthesized, and compared with its analogous monofunctionalized complex. A 1/T-1 NMR relaxometric study of the two amphiphilic complexes incorporated into micelles and liposomes showed an unprecedented relaxivity enhancement for the complex with two lipophilic side arms. This remarkable result, which is attributed to a favorable water exchange rate and increased rigidity of the system resulting from limiting of the local motion of the gadolinium center, represents an important advance in the development of highly efficient nanosystems for MRI applications.