Penetration of Amphotericin B in Human Lung Tissue after Single Liposomal Amphotericin B (AmBisome) Infusion
Penetration of Amphotericin B in Human Lung Tissue after Single Liposomal Amphotericin B (AmBisome) Infusion
复制标题
单脂质体两性霉素 B (AmBisome) 输注后两性霉素 B 在人肺组织中的渗透
DOI：
10.1179/joc.2005.17.1.82
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发表时间：
2005
影响因子：
1.8
通讯作者：
F. Fraschini
中科院分区：
文献类型：
--
作者：
G. Demartini;C. Lequaglie;P. B. Brega Massone;F. Scaglione;F. Fraschini
摘要对18例行开胸肺切除术的原发性或继发性肺癌患者肺组织中两性霉素B的分布进行了研究。术前不同时间给予两性霉素B脂质体1.5 mg/kg静脉滴注1h以上。术中采集血液和肺组织标本（每次采集1例），采用高效液相色谱法检测两性霉素B水平。由于手术需要，我们可以获得输注结束后第10 - 25小时的数据。两性霉素B的血药浓度在静脉输注结束后第10 h逐渐下降至第25 h时的1μg/ml。肺组织样品两性霉素B浓度在第10 h达到最低（约为1 μg/g），随后逐渐升高，在第25 h达到最高值（2.5 μg/g）。
Abstract The distribution of amphotericin B in lung tissue was studied in 18 patients with primary or secondary lung cancer who underwent thoracotomy and pulmonary resection. At different times before surgery the patients were treated with liposomal amphotericin B 1.5 mg/kg by i.v. infusion over 1h. Blood and lung tissue samples were collected during surgery (one subject for each collecting time) and assayed for amphotericin B levels by HPLC. Due to surgical requirements, it was possible to obtain data from the 10th to the 25th h after the end of infusion. Plasma amphotericin B concentrations progressively decreased from 3.4 μ/ml at the 10th h to 1μg/ml at the 25th h after the end of intravenous infusion. In lung tissue samples the lowest amphotericin B concentration (about 1 μg/g) was observed at the 10th h, then a progressive increase was observed with the highest value (2.5 μg/g) determined at the 25th h.