Effect of statin therapy on serum trace element status in dyslipidaemic subjects
Effect of statin therapy on serum trace element status in dyslipidaemic subjects
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DOI：
10.1016/j.jtemb.2005.06.003
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发表时间：
2005-01-01
影响因子：
3.5
通讯作者：
Ferns, GAA
中科院分区：
文献类型：
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作者：
Ghayour-Mobarhan, M;Lamb, DJ;Ferns, GAA
以前没有接受降脂药物治疗的患者(n=20；平均年龄49.15±3.28岁)接受辛伐他汀10 mg/d(n=11)或阿托伐他汀(n=9)治疗4个月。另有14名患者从同一家医院的同一诊所招募作为对照组。这些患者的药物治疗4个月没有改变，测量的参数与他汀类药物组相同。测定治疗前后血清锌、铜、铜蓝蛋白、硒、谷胱甘肽过氧化物酶(GPX)、C反应蛋白(CRP)的浓度及血脂谱。除了降低血清总胆固醇和低密度脂蛋白胆固醇(p<；0.0001)外，他汀类药物治疗还显著降低了平均血清锌(9%，p=0.03)和铜(9%)。C反应蛋白(P<；0.01)、铜蓝蛋白(24%，P<；0.05)和中位数C反应蛋白(45%，P<；0.03)。在对照组患者中没有观察到类似的变化。他汀组和对照组对血清硒、铜/铜蓝蛋白比值或GPX(p>；0.05)均无显著影响。这些变化可能与他汀类药物的已知抗炎特性有关。(C)2005年爱思唯尔股份有限公司。版权所有。
Patients previously not treated with a lipid-lowering agent (n = 20; mean age 49.15 +/- 3.28 years) were treated with either 10 mg/day of Simvastatin (n = 11), or Atorvastatin (n = 9) for 4 months. Fourteen additional patients were recruited from the same clinic at the same hospital as a control group. The medication of these latter patients was unaltered for 4 months and the same parameters were measured as for the statin groups. Serum concentrations of zinc, copper, caeruloplasmin, selenium, glutathione peroxidase (GPx) and C-reactive protein (CRP) were measured together with their lipid profiles pre- and post-treatment. In addition to reducing serum total and low-density lipoprotein (LDL) cholesterol (p < 0.0001), statin treatment was associated with a significant reduction in mean serum zinc (9%,p = 0.03), copper (9%. p < 0.01), caeruloplasmin (24%, p < 0.05), and median CRP (45%, p < 0.03). Similar changes were not observed in the control patients. No significant effects were observed for serum selenium, copper/caeruloplasmin ratio, or GPx (p > 0.05) in either statin or control groups. These changes may be related to the known anti-inflammatory properties of the statin class of drugs. (c) 2005 Elsevier GmbH. All rights reserved.