Assessment of Insulin Resistance and Metabolic Syndrome in Drug Naive Patients of Bipolar Disorder
Assessment of Insulin Resistance and Metabolic Syndrome in Drug Naive Patients of Bipolar Disorder
复制标题
DOI：
10.1007/s12291-012-0292-x
复制
发表时间：
2014-01-01
影响因子：
2.1
通讯作者：
Burman, Prabir
中科院分区：
文献类型：
--
作者：
Guha, Prathama;Bhowmick, Kaushik;Burman, Prabir
对新诊断的双相情感障碍（BPD）患者的空腹血糖、空腹胰岛素、胰岛素抵抗（IR）和代谢综合征（MS）患病率进行了评估，并与年龄、性别和种族匹配的对照人群进行了比较。55例bpd - 1患者（15-65岁），非糖尿病，未怀孕，至少6个月未用药。使用DSM-IV轴I障碍（SCID IV）的结构化临床访谈进行诊断。使用胰岛素抵抗稳态模型（HOMA-IR）评估IR；根据国家胆固醇教育计划-成人治疗小组III （NCEP-ATP III）定义质谱。将数据与25名健康对照进行比较。与对照组相比，BPD患者空腹血浆胰岛素（13.2 +/- 9.2 vs. 4.68 +/- 3.1 mu IU/ml, p < 0.05）、餐后血浆胰岛素（27.2 +/- 14.5 vs. 18.1 +/- 9.3 mu IU/ml, p < 0.05）和HOMAIR （3.16 +/- 2.2 vs. 1.19 +/- 0.8, p < 0.05）的平均水平均显著高于对照组。BPD患者空腹血糖、血清甘油三酯和血压高于临界值的比例明显高于对照组，而腰围和血清高密度脂蛋白胆固醇的比例无显著差异。BPD患者的IR患病率明显高于对照组（26/55比2/25，z值9.97,p < 0.05），而MS患病率两组间差异无统计学意义。在BPD患者中，逻辑回归分析显示，年龄、性别或当前情绪状态（抑郁/躁狂）对是否存在MS或IR升高没有显著的预测作用。
The levels of fasting glucose, fasting insulin, insulin resistance (IR) and the prevalence of metabolic syndrome (MS) in a sample population of bipolar disorder (BPD) patients who were newly diagnosed and psychotropically naive were assessed and compared with an age, sex and racially matched control population. 55 BPD-I patients (15-65 years) who were non-diabetic, nonpregnant, and drug naive for a period of at least 6 months were included in the study. Diagnosis was made using the structured clinical interview for DSM-IV axis I disorders (SCID IV). IR was assessed using homeostasis model of insulin resistance (HOMA-IR); MS was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). Data were compared with 25 healthy controls. BPD patients had significantly higher mean levels of fasting plasma insulin (13.2 +/- 9.2 vs. 4.68 +/- 3.1 mu IU/ml, p < 0.05), postprandial plasma insulin (27.2 +/- 14.5 vs. 18.1 +/- 9.3 mu IU/ml, p < 0.05) and a higher value of HOMAIR (3.16 +/- 2.2 vs. 1.19 +/- 0.8, p < \0.05) when compared to the controls. A significantly higher proportion of patients of BPD compared to controls were manifesting levels of fasting plasma glucose, serum triglyceride and blood pressure higher than the cut off while waist circumference and serum HDL cholesterol failed to show any significant difference in the proportion. There was a significantly higher proportion of prevalence of IR between BPD cases and controls (26/55 vs. 2/25, z value 9.97, p < 0.05) while there was no significant difference in proportion of prevalence of MS between these two groups. Within BPD patients, logistic regression analysis showed that age, sex or current mood status (depressed/manic) were not significantly predictive of presence or absence of MS or increased IR.