The FBN rat model of aging: investigation of ABR waveforms and ribbon synapse changes.
The FBN rat model of aging: investigation of ABR waveforms and ribbon synapse changes.
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DOI：
10.1016/j.neurobiolaging.2017.09.034
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发表时间：
2018-03
影响因子：
4.2
通讯作者：
Cox BC
中科院分区：
文献类型：
--
作者：
Cai R;Montgomery SC;Graves KA;Caspary DM;Cox BC
在65岁及以上的人群中，有三分之一的人经历过与年龄有关的听力损失，这可能会使社会衰弱。从历史上看，与年龄相关的阈值变化、语言理解能力的丧失和耳蜗毛细胞（hc）的丧失之间的相关性很差。我们研究了Fisher Brown Norway （FBN）大鼠（一种被广泛研究的衰老大鼠模型）在四个年龄阶段的带状突触数量变化。与之前在小鼠/Wistar大鼠中的研究相比，我们发现在20个月(m)之前带状突触的损失最小，在24m和28m大鼠中，在4 kHz时存在显著差异。在低至中频区域，在24m和28m处观察到明显的外HC损失。与年龄相关的ABR波I振幅的降低和阈值的增加与带状突触的丧失密切相关。在click， 2,4和24khz时，波的V/I比率随年龄增长而增加。总之，我们发现FBN大鼠耳蜗中的带状突触在其寿命的60%之前都表现出抗衰老的能力，这表明物种/品系的差异可能是老化的中央处理器的外围输入减少的基础。
Age-related hearing loss is experienced by one-third of individuals 65 years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss of speech understanding, and loss of cochlear hair cells (HCs). We examined changes in ribbon synapse number at four ages in Fisher Brown Norway (FBN) rats, an extensively studied rat model of aging. In contrast to previous work in mice/Wistar rats, we found minimal ribbon synapse loss before 20 months (m), with significant differences in 24m and 28m rats at 4 kHz. Significant outer HC loss was observed at 24m and 28m in low to mid-frequency regions. Age-related reductions in ABR wave I amplitude and increases in threshold were strongly correlated with ribbon synapse loss. Wave V/I ratios increased across age for click, 2, 4, and 24 kHz. Together, we find that ribbon synapses in the FBN rat cochlea show resistance to aging until ~60% of their lifespan, suggesting species/strain differences may underpin decreased peripheral input into the aging central processor.
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DOI：
10.18632/aging.101045
发表时间：
2016-09-23
期刊：
Aging
影响因子：
--
作者：
Frisina RD;Ding B;Zhu X;Walton JP
通讯作者：
Walton JP
影响因子：
56.9
作者：
BUCHWALD, JS;HUANG, CM
通讯作者：
HUANG, CM
影响因子：
2.8
作者：
Frisina, Robert D.;Walton, Joseph P.
通讯作者：
Walton, Joseph P.
影响因子：
5.7
作者：
Dalton, DS;Cruickshanks, KJ;Nondahl, DM
通讯作者：
Nondahl, DM
影响因子：
3.3
作者：
Caspary, DM;Holder, TM;Naritoku, DK
通讯作者：
Naritoku, DK