The hypoxic tumor microenvironment: A driving force for breast cancer progression.
The hypoxic tumor microenvironment: A driving force for breast cancer progression.
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DOI：
10.1016/j.bbamcr.2015.05.036
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Semenza GL
中科院分区：
文献类型：
--
作者：
Semenza GL
瘤内缺氧是乳腺癌的常见现象，与转移和患者死亡率显着增加的风险相关。缺氧诱导因子激活大量编码蛋白质的基因转录，这些蛋白质可促进原发性肿瘤血管化和生长、基质细胞募集、细胞外基质重塑、转移前生态位形成、细胞运动、局部组织侵袭、转移部位外渗以及维持产生继发性肿瘤所需的癌症干细胞表型。最近的临床前研究表明，细胞毒性化疗与抑制缺氧诱导因子的药物相结合可能会改善三阴性乳腺癌女性的预后。
Intratumoral hypoxia is a common finding in breast cancer and is associated with a significantly increased risk of metastasis and patient mortality. Hypoxia-inducible factors activate the transcription of a large battery of genes encoding proteins that promote primary tumor vascularization and growth, stromal cell recruitment, extracellular matrix remodeling, premetastatic niche formation, cell motility, local tissue invasion, extravasation at sites of metastasis, and maintenance of the cancer stem cell phenotype that is required to generate secondary tumors. Recent preclinical studies suggest that the combination of cytotoxic chemotherapy with drugs that inhibit hypoxia-inducible factors may improve outcome for women with triple-negative breast cancer.