Changes in Intraocular Pressure During Prone Spine Surgery Under Propofol and Sevoflurane Anesthesia
Changes in Intraocular Pressure During Prone Spine Surgery Under Propofol and Sevoflurane Anesthesia
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DOI：
10.1097/ana.0b013e31823fe822
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发表时间：
2012-04-01
影响因子：
3.7
通讯作者：
Furuya, Hitoshi
中科院分区：
文献类型：
--
作者：
Sugata, Aiko;Hayashi, Hironobu;Furuya, Hitoshi
背景：俯卧位脊柱手术期间眼压(IOP)升高。虽然异丙酚和七氟醚在此类手术中被广泛使用，但还没有数据比较异丙酚和七氟醚麻醉下的眼压变化。因此，本研究旨在探讨俯卧位脊柱手术中异丙酚和七氟醚麻醉下眼压的变化。方法：24例俯卧位脊柱手术患者，在机构批准和知情同意后，观察其眼压的变化。患者被随机分为两组：异丙酚组或七氟醚组。给予异丙酚或七氟醚以维持脑电双频指数在40至60之间。分别于麻醉诱导后10分钟(基线)、俯卧位10、60、120分钟、恢复仰卧位10分钟后用TonOpen XL手持式眼压计测量眼压。两组患者俯卧位后眼压均较术前显著升高(异丙酚组：从8.9±3.5至21.9±5.0 mm Hg；七氟醚组：从11.6±-3.9 mm Hg至24.8±3.4 mm Hg；P<；0.05)。虽然七氟醚组的眼压高于异丙酚组，但差异无统计学意义。结论：七氟醚或异丙酚的选择对俯卧位脊柱手术的眼压变化无明显影响。
Background: Intraocular pressure (IOP) has been shown to increase during prone spine surgery. Although propofol and sevoflurane have been widely used during such surgery, there have been no data to compare the IOP changes under propofol and sevoflurane anesthesia. The present study was therefore conducted to investigate IOP changes under propofol and sevoflurane anesthesia during prone spine surgery.Method: After institutional approval and informed consent, 24 patients undergoing prone spine surgery were studied. Patients were randomly allocated to 1 of 2 groups: the propofol or sevoflurane group. Propofol or sevoflurane was administered to maintain the bispectral index between 40 and 60. The IOP was measured using a Tonopen XL hand-held tonometer 10 minutes after induction of anesthesia in the supine position (baseline), 10, 60, and 120 minutes after positioning in the prone position, and 10 minutes after returning to the supine position.Results: There were no significant differences in IOP values at baseline between the 2 groups. IOP values after positioning in the prone position were significantly higher than those at baseline in both groups (propofol group: from 8.9 +/- 3.5 to 21.9 +/- 5.0mm Hg; sevoflurane group: from 11.6 +/- 3.9 to 24.8 +/- 3.4mm Hg; P < 0.05). Although IOP values were higher in the sevoflurane group than in the propofol group, the differences in IOP values were not statistically significant.Conclusions: The results indicated that the choice of anesthetic agent, sevoflurane or propofol, did not have significant effects on IOP changes during a relatively short interval of prone spine surgery.