The use of oral amoxycillin for the treatment of actinomycosis. A clinical and in vitro study
The use of oral amoxycillin for the treatment of actinomycosis. A clinical and in vitro study
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使用口服阿莫西林治疗放线菌病。
DOI：
10.1038/sj.bdj.4805331
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发表时间：
1984
影响因子：
2.6
通讯作者：
M. Martín
中科院分区：
文献类型：
--
作者：
M. Martín
86株临床分离的放线菌中有85株为A.对青霉素和阿莫西林的最小抑菌浓度为0.05 ~ 6.0 μg/ml，而阿莫西林的最小抑菌浓度均不超过0.8 μg/ml。10例放线菌病患者采用手术和口服阿莫西林500 mg每日4次相结合的方法治疗，反应良好，所有病例均在不到6周的时间内获得临床缓解。根据这些结果，口服阿莫西林和手术联合治疗口腔或颈面部放线菌病是合适的。israelii，1A. viscosus）和3（A. israelii、黑腹拟步行虫A. viscosus、A. naeslundii）对苄青霉素和阿莫西林的敏感性。苄青霉素的最小抑菌浓度为0.05-6 μg/ml，而阿莫西林的最小抑菌浓度不超过0.8 μg/ml。10例口腔外感染患者接受了手术和口服阿莫西林500 mg 4次/天的联合治疗。所有病例均在6周内达到临床缓解。
The sensitivity of 89Actinomycesstrains [85 of the 86 clinical isolates wereA. israelii] to benzylpenicillin and amoxycillin has been testedin vitro.Minimal inhibitory concentration values for benzylpenicillin varied from 0.05 to 6.0 µg/ml whilst those for amoxycillin did not exceed 0.8 µg/ml for any isolates. Ten patients with actinomycosis were treated by a combination of surgery and oral amoxycillin 500 mg four times daily and responsed well, clinical resolutions being achieved in all cases in less than six weeks. On the basis of these results, a combination of oral amoxycillin and surgery would be appropriate for cases of oral or cervicofacial actinomycosis.newline˜ASADDITIONAL ABSTRACT:The sensitivity of 89Actinomycesisolates, including 86 (85A. israelii,1A. viscosus) from clinical cases and 3 (A. israelii, A. viscosus, A. naeslundii) from type culture collections, to benzylpenicillin and amoxycillin was tested. The min. inhibitory concn for benzylpenicillin was 0.05-6 µg/ml while that for amoxycillin did not exceed 0.8 µg/ml. Ten patients with extra-oral infection were treated with a combination of surgery and oral amoxycillin at 500 mg 4 times/day. Clinical resolution was achieved in all cases in less than 6 weeks.