Sleep Disturbance in Early Pregnancy, but Not Inflammatory Cytokines, May Increase Risk for Adverse Pregnancy Outcomes.
Sleep Disturbance in Early Pregnancy, but Not Inflammatory Cytokines, May Increase Risk for Adverse Pregnancy Outcomes.
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怀孕早期的睡眠障碍可能会增加不良妊娠结果的风险，但炎症细胞因子不会。
DOI：
10.1007/s12529-020-09880-x
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发表时间：
2021
影响因子：
2.7
通讯作者：
Feliciano,Leilani
中科院分区：
文献类型：
--
作者：
Okun,MicheleL;Obetz,Vanessa;Feliciano,Leilani
背景目前尚不清楚怀孕期间睡眠的主观或客观指标是否与妊娠结局更相关。此外，还不清楚主观指数（即，那些可能受心理思想和情绪影响的人）比客观测量更有可能改变炎性细胞因子.从166名孕妇收集睡眠的主观和客观测量。在妊娠早期（10-20周）的三个2周期间，从日记和活动记录仪中确定睡眠数据，包括总体和变异性测量。测定空腹晨血样本的细胞因子（IL-6、IFN-γ和TNF-α）。睡眠、压力和抑郁问卷也被收集。重复测量方差分析，回归模型，和independentttests被用来分析data. ResultsDiary评估的总睡眠时间（p<0.05）和actigraphy-assessed睡眠潜伏期（p= 0.05）与胎龄呈负相关。活动描记器评估的睡眠潜伏期的变异性（p<0.01）与婴儿体重呈负相关。没有一种细胞因子与任何结果相关。t检验显示有并发症的患者年龄较大（p< .05），且孕前BMI较高（p< .05），自我报告的压力较高（p<0.05），IFN-γ降低（p< .05）。结论研究结果表明，睡眠潜伏期越长，变化越大，睡眠持续时间越短，与较短的胎龄或出生体重较低的婴儿有关。总的来说，研究结果表明，在低风险，健康的孕妇样本中，睡眠障碍不会对不良分娩结果构成实质性风险。
BackgroundIt is unclear whether subjective or objective measures of sleep during pregnancy are more pertinent to pregnancy outcomes. Moreover, it is unclear as to whether subjective indices (i.e., those likely influenced by psychological thoughts and emotions) are more likely than objective measures to modify inflammatory cytokines.MethodSubjective and objective measures of sleep were collected from 166 pregnant women. Sleep data, both aggregate and variability measures, from diary and actigraphy, were ascertained for three 2-week periods during early gestation (10–20 weeks). A fasting morning blood sample was assayed for the cytokines (IL-6, IFN-γ, and TNF-α). Sleep, stress, and depression questionnaires were also collected. Repeated measures ANOVAs, regression models, and independentttests were used to analyze the data.ResultsDiary-assessed total sleep time (p< .05) and actigraphy-assessed sleep latency (p= .05) were negatively associated with gestational age. Variability in actigraphy-assessed sleep latency (p< .01) was negatively associated with infant weight. None of the cytokines was associated with any of the outcomes.ttests revealed that those with a complication were older (p< .05) and had higher pre-pregnancy BMI (p< .05), higher self-reported stress (p< .05), and lower IFN-γ (p< .05).ConclusionFindings suggest that longer and more variable sleep latency, as well as shorter sleep duration, is associated with shorter gestational age or a lower birth weight infant. Overall, the findings suggest that among a low-risk, healthy sample of pregnant women, sleep disturbance does not pose a substantial risk for adverse delivery outcomes.