Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients.
Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients.
复制标题
新诊断的 2 型糖尿病患者外周血增生素 A 的循环水平升高
DOI：
10.3389/fendo.2021.737624
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发表时间：
2021
影响因子：
5.2
通讯作者：
Yuan G
中科院分区：
文献类型：
--
作者：
Deng X;Cai Z;Li Y;Wu X;Zhao L;Li H;Chen K;Zhang P;Wang C;Zhao Z;Yang L;Yuan G
外胚层发育异常蛋白A（EDA）是一种新发现的肝细胞因子，近年来被认为与糖脂代谢紊乱密切相关，但其病理生理作用尚不清楚。本研究首次测定了初诊2型糖尿病（T2 DM）患者血清EDA水平，并探讨血清EDA水平与各项代谢指标的关系。本研究共入组184例受试者，包括92例新诊断的T2 DM受试者和92例年龄和性别匹配的正常葡萄糖耐量（NGT）受试者。采用酶联免疫吸附试验（ELISA）测定血清EDA水平。口服葡萄糖耐量试验，糖化血红蛋白c（HbA 1c）和胰岛素也进行了测量。2型糖尿病组血清EDA水平显著高于正常对照组（359.91 ± 117.99 vs.265.82 ± 86.51pg/ml，p < 0.001）。血清EDA水平与体重指数（BMI）、腰臀比（WHR）、空腹血糖（FPG）、糖化血红蛋白（HbA 1c）、餐后2 h血糖（2 hPG）、空腹血浆胰岛素（FIns）、空腹C肽（FCP）、甘油三酯（TG）、HOMA-IR呈正相关，与高密度脂蛋白胆固醇（HDL-c）、HOMA-β呈负相关（p < 0.05）。多元逐步回归分析显示2 hPG和FIns是影响血清EDA水平的独立因素（p < 0.05）。Logistic回归分析显示，血清EDA水平与T2 DM有显著的独立相关性（p < 0.05）。2型糖尿病患者血清EDA水平明显升高，提示EDA可能在2型糖尿病的发生发展中起一定作用。
Ectodysplasin A (EDA), a newly discovered hepatokine, has recently been considered to be closely related to glycolipid metabolism disorders, but the pathophysiological effects of EDA are still poorly understood. This study was the first time to determine the level of serum EDA in newly diagnosed type 2 diabetes mellitus (T2DM) patients, and to explore the relationships between serum EDA levels and various metabolic indexes. A total of 184 subjects were enrolled in the study, including 92 subjects with newly diagnosed T2DM and 92 subjects with age- and sex-matched normal glucose tolerance (NGT). Serum EDA levels were determined using enzyme-linked immunosorbent assay (ELISA). Oral glucose tolerance test, glycosylated hemoglobin c (HbA1c), and insulin were also measured. Serum EDA levels were significantly increased in the T2DM group than in the NGT group (359.91 ± 117.99 vs. 265.82 ± 86.51 pg/ml, p < 0.001). Serum EDA levels were positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting plasma glucose (FPG), HbA1c, 2-hour postprandial plasma glucose (2hPG), fasting plasma insulin (FIns), fasting C peptide (FCP), triglyceride (TG), HOMA-IR, and negatively correlated with high-density lipoprotein cholesterol (HDL-c) and HOMA-β (p < 0.05). Multiple stepwise regression analysis demonstrated that 2hPG and FIns were independent influencing factors of serum EDA level (p < 0.05). Logistic regression analysis showed that serum EDA level was significantly independently correlated with T2DM (p < 0.05). Serum EDA levels are significantly higher in T2DM patients, suggesting that EDA may play a role in the occurrence and development of T2DM.