Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease
Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease
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DOI：
10.1016/j.jhep.2016.04.023
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发表时间：
2016-09-01
影响因子：
25.7
通讯作者：
de Ledinghen, Victor
中科院分区：
文献类型：
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作者：
Boursier, Jerome;Vergniol, Julien;de Ledinghen, Victor
背景与目的：NAFLD 非常普遍，但只有一小部分患者会出现晚期肝纤维化，且肝脏相关预后受损。我们的目的是比较 FibroScan 的血液纤维化测试和肝脏硬度测量 (LSM) 对 NAFLD 肝纤维化的诊断和预后评估。方法：在一项横断面研究中评估诊断准确性，该研究包括 452 名 NAFLD 患者的肝活检（NASH-CRN 纤维化阶段）、LSM 和八项血液纤维化测试（BARD、NAFLD 纤维化评分、FibroMeter(NAFLD)、天冬氨酸氨基转移酶转血小板）比率指数 (APRI)、FIB4、FibroTest、Hepascore、FibroMeter(V2G)）。在一项纳入 360 名 NAFLD 患者的纵向研究中评估了预后准确性。结果：LSM 和 FibroMeterV2G 是横断面研究中表现最好的两种测试：晚期纤维化 (F3/4) 的 AUROC 分别为 0.831 +/- 0.019 和 0.817 +/- 0.020 (p
Background & Aims: NAFLD is highly prevalent but only a small subset of patients develop advanced liver fibrosis with impaired liver-related prognosis. We aimed to compare blood fibrosis tests and liver stiffness measurement (LSM) by FibroScan for the diagnosis of liver fibrosis and the evaluation of prognosis in NAFLD.Methods: Diagnostic accuracy was evaluated in a cross-sectional study including 452 NAFLD patients with liver biopsy (NASH-CRN fibrosis stage), LSM, and eight blood fibrosis tests (BARD, NAFLD fibrosis score, FibroMeter(NAFLD), aspartate aminotransferase to platelet ratio index (APRI), FIB4, FibroTest, Hepascore, FibroMeter(V2G)). Prognostic accuracy was evaluated in a longitudinal study including 360 NAFLD patients.Results: LSM and FibroMeterV2G were the two best-performing tests in the cross-sectional study: AUROCs for advanced fibrosis (F3/4) were, respectively, 0.831 +/- 0.019 and 0.817 +/- 0.020 (p