Axially chiral guanidine as enantioselective base catalyst for 1,4-addition reaction of 1,3-dicarbonyl compounds with conjugated nitroalkenes
Axially chiral guanidine as enantioselective base catalyst for 1,4-addition reaction of 1,3-dicarbonyl compounds with conjugated nitroalkenes
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DOI：
10.1021/ja057848d
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发表时间：
2006-02-08
影响因子：
15
通讯作者：
Yaguchi, Y
中科院分区：
文献类型：
--
作者：
Terada, M;Ube, H;Yaguchi, Y
提出了一种新的设计手性胍类分子的策略，其特点是引入轴向手性联萘骨架。由此开发的轴向手性胍催化剂促进了1，3-二羰基化合物与广泛的共轭硝基烯烃的高度对映选择性的1，4-加成反应，并显示出极高的催化活性。
A new strategy for designing chiral guanidine molecules is presented, which features the introduction of an axially chiral binaphthyl backbone. The axially chiral guanidine catalysts thus developed facilitated the highly enantioselective 1,4-addition reaction of 1,3-dicarbonyl compounds with a broad range of conjugated nitroalkenes and showed extremely high catalytic activity.